{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:47:37Z","timestamp":1791074857059,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>Amino acid loss, plasma concentration, and the relationship between amino acid intake and balance during continuous hemodiafiltration (CHD) were investigated in a prospective, nonrandomized study of trauma patients exhibiting the systemic inflammatory response with acute renal failure. Data were compared with those from a group of similar patients who had maintained renal function (control). Both groups received similar amounts of nonprotein calories (3015 \u00b1 753 nonprotein calories per day in the control group <jats:italic>vs<\/jats:italic> 3077 \u00b1 1018 nonprotein calories per day in the CHD group) and amino acids (2.24 \u00b1 0.36 g\/kg per day in the control group <jats:italic>vs<\/jats:italic> 2.19 \u00b1 0.48 g\/kg per day in the CHD group) via the parenteral route. Amino acid solutions were either 19% or 45% branched\u2010chain amino acid enriched. Studies were performed every 12 hours for a maximum of 6 days. Amino acid loss was 2.5 \u00b1 2.3 g\/12 h in the control group <jats:italic>vs<\/jats:italic> 6.6 \u00b1 2.4 g\/12 h in the CHD group (<jats:italic>p<\/jats:italic> &lt;.0001). Increasing the dialysate rate from 15 to 30 mL\/min increased amino acid loss from 5.7 \u00b1 1.7 to 7.9 \u00b1 2.6 g\/12 h (<jats:italic>p<\/jats:italic> &lt;.0001). Amino acid loss was unrelated to amino acid intake but was directly related to plasma amino acid concentration, CHD effluent volume, and the efficiency of filtration as measured by the ratio of filtered urea nitrogen to blood urea nitrogen (<jats:italic>R<\/jats:italic> <jats:sup>2<\/jats:sup> =.69). A linear relationship was found between amino acid intake and balance (<jats:italic>R<\/jats:italic> <jats:sup>2<\/jats:sup> =.991). The patterns of plasma amino acid concentrations were consistent with metabolic changes wrought by a combination of sepsis and multiple organ dysfunction and type of amino acid intake but seemed unaffected by increased amino acid loss in CHD effluent. Amino acid losses were 2 to 3 times greater from CHD than from normal kidney. However, CHD amino acid losses may not be clinically significant unless amino acid intake is restricted to levels used typically in traditional hemodialysis. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>17<\/jats:bold>:551\u2013561, 1993)<\/jats:p>","DOI":"10.1177\/0148607193017006551","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"551-561","source":"Crossref","is-referenced-by-count":45,"title":["Amino Acid Loss and Plasma Concentration During Continuous Hemodiafiltration"],"prefix":"10.1002","volume":"17","author":[{"given":"David C.","family":"Frankenfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Badellino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Neal","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles E.","family":"Wiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199111000-00015"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198703000-00011"},{"key":"e_1_2_1_4_1","first-page":"100","article-title":"Amino acid removal during continuous arteriovenous hemodialysis in patients with acute renal failure receiving total parenteral nutrition (Abstr)","volume":"15","author":"Sigler MH","year":"1990","journal-title":"Intensiv Behandlung"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199112000-00012"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198905000-00002"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199206000-00025"},{"key":"e_1_2_1_8_1","first-page":"445","volume-title":"The Scientific Management of Surgical Patients","author":"Coleman B.","year":"1983"},{"key":"e_1_2_1_9_1","volume-title":"Linear Regression Analysis","author":"Seber GAF","year":"1977"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199005000-00004"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0620299"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607190014004201"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-10-821"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199005000-00019"},{"key":"e_1_2_1_15_1","first-page":"22S","article-title":"Glutamine synthesis from leucine after trauma (Abstr)","volume":"13","author":"Yoshida S.","year":"1989","journal-title":"JPEN"},{"key":"e_1_2_1_16_1","first-page":"378","article-title":"Increased dependence of leucine in posttraumatic sepsis: Leucine\/tyrosine clearance ratio as an indicator of hepatic impairment in septic multiple organ failure syndrome","volume":"98","author":"Pittiruti M.","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_17_1","first-page":"225","article-title":"Pathologic synergy in the cardiovascular, respiratory, and metabolic response to injury by cirrhosis and\/or sepsis: A manifestation of a common metabolic defect","volume":"117","author":"Siegel JH","year":"1982","journal-title":"Ann Surg"},{"key":"e_1_2_1_18_1","first-page":"436","article-title":"Liver amino acids in sepsis","volume":"97","author":"Roth E.","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_1_19_1","first-page":"451","volume-title":"Amino acid metabolism in chronic renal failure. IN Amino Acid Metabolism and Medical Applications","author":"Kopple JD","year":"1983"},{"key":"e_1_2_1_20_1","first-page":"163","article-title":"Physiologic and metabolic correlations in human sepsis","volume":"86","author":"Siegel JH","year":"1979","journal-title":"Surgery"},{"key":"e_1_2_1_21_1","first-page":"531","article-title":"Effects of parenteral alimentation on amino acid metabolism in septic patients","volume":"88","author":"Clowes GHA","year":"1980","journal-title":"Surgery"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197809000-00017"},{"key":"e_1_2_1_23_1","first-page":"411","article-title":"Do parenteral nutrition solutions enriched with high concentrations of branched\u2010chain amino acids offer significant benefits to stressed patients","volume":"23","author":"Teasley KM","year":"1989","journal-title":"Drug Intell Clin Pharm"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607193017006551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:45:16Z","timestamp":1760640316000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607193017006551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1177\/0148607193017006551"],"URL":"https:\/\/doi.org\/10.1177\/0148607193017006551","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}