{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:29:11Z","timestamp":1760660951710,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1994,5,1]],"date-time":"1994-05-01T00:00:00Z","timestamp":767750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:p>Parenteral nutrients can be used to manipulate cell proliferation after partial hepatectomy. The relationship among macronutrients\u2014glucose, monoacetoacetin, amino acids\u2014 and liver regeneration after partial hepatectomy was investigated. Male rats were anesthetized, received a 70% hepatectomy, and received a low\u2010dose infusion of (1) glucose or (2) monoacetoacetin and a high\u2010dose infusion of (3) glucose, (4) glycerol\u2010glucose, or (5) monoacetoacetin\u2010glucose beginning 6 hours after surgery. The five nonprotein nutrient combinations were infused with and without amino acids. Rats were killed 48 hours after partial hepatectomy, and the label and mitotic indices were determined. Each of the five treatments had a higher label index with amino acids present than with amino acids absent. Low\u2010dose glucose and monoacetoacetin as well as high\u2010dose glucose and glucose\u2010glycerol had higher mitotic indices with amino acids than without amino acids. High\u2010dose monoacetoacetin\u2010glucose was associated with a greater mitotic index than was any other nonprotein substrate treatment, and this response was independent of amino acids being present or absent. In summary, (1) amino acids were needed for maximal cell proliferation rate; (2) the absence of amino acids and not the presence of glucose resulted in reduction of the label and mitotic indices for regenerating liver; (3) high\u2010dose monoacetoacetin increased mitosis with or without amino acids; and (4) monoacetoacetin activity was dose dependent. The results indicate that the best nutrient for treatment of patients with liver injury is acetoacetate. The second best nutrient would be the combination of high\u2010dose glucose and amino acids. The results further indicate that glucose should not be administered to patients with liver injury unless accompanied by amino acids. 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