{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:35:23Z","timestamp":1760661323113,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:p>Recombinant human insulin\u2010like growth factor\u20101 (rhIGF\u20101) is currently used experimentally to treat patients with insulin\u2010resistant diabetes mellitus, impaired growth, protein malnutrition, and osteoporosis. We report here the case of a marked transient alteration in consciousness in a healthy 22\u2010year\u2010old man who was given an IV infusion of a relatively low dose of rhIGF\u20101 for 1 hour. This individual developed the sudden onset of dizziness, nausea, coldness, air hunger, and pallor. He became unresponsive to simple questions and experienced diaphoresis, a feeling of warmth, and paresthesias. Although there was a mild fall in heart rate and blood pressure, these hemodynamic effects did not appear sufficient to cause the altered mentation. There were no changes in serum glucose, phosphorus, or potassium that could seem to account for these events. This individual recovered completely several minutes after stopping the rhIGF\u20101 infusion. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> 19:231\u2013233, 1995)<\/jats:p>","DOI":"10.1177\/0148607195019003231","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"231-233","source":"Crossref","is-referenced-by-count":7,"title":["Altered Mental Function During Intravenous Infusion of Recombinant Human Insulin\u2010Like Growth Factor 1"],"prefix":"10.1002","volume":"19","author":[{"given":"Denis","family":"Fouque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Tayek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Kopple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707163170303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91594-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271205"},{"key":"e_1_2_1_5_1","first-page":"414","article-title":"Insulin\u2010like growth factor\u20101 (IGF\u20101) causes anabolism in malnourished CAPD patients","volume":"4","author":"Peng S.","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_1_6_1","unstructured":"Ciba Investigator's brochure recombinant human insulin like growth factor 1 (rhIGF\u20101). HP Guler (Ed.) with authorization"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308263290917"},{"key":"e_1_2_1_8_1","first-page":"E130","article-title":"Diverse effects of insulin\u2010like growth factor\u2010I on glucose, lipid, and amino acid metabolism","volume":"262","author":"Boulware SD","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115796"},{"key":"e_1_2_1_10_1","first-page":"E714","article-title":"Changes of sympathetic nerve activity induced by 2\u2010deoxy\u2010D\u2010glucose infusion in humans","volume":"256","author":"Fagius J.","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115119"},{"key":"e_1_2_1_12_1","first-page":"230","article-title":"Recombinant human insulin\u2010like growth factor\u20101 increases forearm blood flow","volume":"79","author":"Copeland KC","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_1_13_1","first-page":"1192","article-title":"Low dose recombinant human insulin\u2010like growth factor\u2010I fails to affect protein anabolism but inhibits islet cell secretion in humans","volume":"75","author":"Mauras N.","year":"1992","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607195019003231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:36:09Z","timestamp":1760639769000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607195019003231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["10.1177\/0148607195019003231"],"URL":"https:\/\/doi.org\/10.1177\/0148607195019003231","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}