{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:11:23Z","timestamp":1773151883147,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>Osteomyelitis of the spine is a well\u2010recognized delayed manifestation of septicemia but has not been recognized as a complication of total parenteral nutrition. We report five cases of spinal osteomyelitis that were clinically recognized 1 to 13 months after total parenteral nutrition catheter\u2010induced septicemia. Radiographic evidence of osteomyelitis was seen in all five patients. In three patients, culture of bony aspirates was positive for the same organism as from the blood. In one case, the diagnosis was established by histology, and in one the diagnosis was based on radiographic and radionuclide evidence of osteomyelitis. The organism responsible was <jats:italic>Staphylococcus aureus<\/jats:italic> in two cases, <jats:italic>Candida albicans<\/jats:italic> in another two cases and <jats:italic>C tropicalis<\/jats:italic> in one case. The septic episode that preceded osteomyelitis was treated with systemic antibiotics and catheter removal in four patients, and antibiotics without catheter removal in one patient. Nevertheless, osteomyelitis occurred, requiring bracing or operative debridement as well as prolonged antibiotic therapy. Spinal osteomyelitis may occur as a delayed manifestation of total parenteral nutrition catheter\u2010induced septicemia. Prompt and effective treatment of septicemia is indicated but may not always be sufficient. Clinical suspicion is the key to the correct and early diagnosis of osteomyelitis and therefore to adequate treatment. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>19:<\/jats:bold>291\u2014295, 1995)<\/jats:p>","DOI":"10.1177\/0148607195019004291","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"291-295","source":"Crossref","is-referenced-by-count":20,"title":["Spinal Osteomyelitis After TPN Catheter\u2010Induced Septicemia"],"prefix":"10.1002","volume":"19","author":[{"given":"Francesca A.","family":"Corso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald B.","family":"Shaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce M.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.6.0878"},{"key":"e_1_2_1_3_1","first-page":"62","article-title":"Pyogenic spinal osteomyelitis: A review of 61 cases","volume":"99","author":"Silverthorn KG","year":"1986","journal-title":"Aust NZ Med J"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380020161021"},{"key":"e_1_2_1_5_1","first-page":"1680","article-title":"Hematogenous pyogenic vertebral osteomyelitis: Diagnostic value of radionuclide bone imaging","volume":"27","author":"Adatepe MH","year":"1986","journal-title":"J Nucl Med"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.1.143"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90840-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540874"},{"key":"e_1_2_1_9_1","first-page":"757","volume-title":"The Spine","author":"La Rocca H.","year":"1982"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90351-W"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/1.5.754"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2316(85)80005-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199012000-00015"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.4001933"},{"key":"e_1_2_1_15_1","first-page":"1","volume-title":"Bacterial Adherence","author":"Ofec I.","year":"1980"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(85)90386-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-5-651"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0891-5520(20)30358-5","article-title":"Antibiotic therapy for osteomyelitis","volume":"4","author":"Gentry LO","year":"1990","journal-title":"Inf Dis Clin N Am"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3629258"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0891-5520(20)30353-6","article-title":"Musculoskeletal infection, microbial adhesion, and antibiotic resistance","volume":"4","author":"Gristina AG","year":"1990","journal-title":"Inf Dis Clin N Am"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/15.5.517"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607195019004291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:01:13Z","timestamp":1760630473000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607195019004291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1177\/0148607195019004291"],"URL":"https:\/\/doi.org\/10.1177\/0148607195019004291","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}