{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:36:47Z","timestamp":1760888207521,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> We demonstrated that recombinant human insulin\u2010like growth factor\u2010I (rhIGF\u2010I) or growth hormone (rhGH) produces identical body weight gain during total parenteral nutrition (TPN) in surgically\u2010stressed rats. Our current objective was to evaluate the relative anabolic and metabolic effects associated with administration of rhIGF\u2010I and\/or rhGH during hypocaloric TPN in rats with dexamethasone (DEX)\u2010induced catabolism. <jats:italic>Methods:<\/jats:italic> Male Sprague\u2010Dawley rats (~270 g) given TPN and DEX were treated with IGF\u2010I and\/or GH for 6 days. Two control groups, TPN and DEX, were included. Anabolic response was assessed by change in body protein content and nitrogen balance. Metabolic response was assessed by determination of serum concentrations of IGF\u20101, IGF binding proteins (IGFBPs), insulin, glucose, triacylglycerol, glycerol, and free fatty acids. <jats:italic>Results:<\/jats:italic> Compared with GH, IGF\u2010I attenuated DEX\u2010induced loss of body protein and decreased serum concentrations of glucose, free fatty acids, glycerol, and triglycerol. Treatment with IGF\u2010I plus GH showed an anabolic response similar to IGF\u2010I alone. IGF\u2010I and\/or GH increased serum concentrations of IGF\u2010I and IGFBP\u20103. IGF\u2010I alone increased serum level of IGFBP\u20105. <jats:italic>Conclusion:<\/jats:italic> Administration of IGF\u2010I, but not GH, attenuates DEX\u2010induced protein catabolism in association with increased insulin sensitivity in rats. Glucocorticoid excess may limit the response to GH therapy during TPN. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>20:<\/jats:bold> 171\u2013177, 1996)<\/jats:p>","DOI":"10.1177\/0148607196020003171","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"171-177","source":"Crossref","is-referenced-by-count":21,"title":["Insulin\u2010Like Growth Factor\u2010I but Not Growth Hormone Attenuates Dexamethasone\u2010Induced Catabolism in Parenterally Fed Rats"],"prefix":"10.1002","volume":"20","author":[{"given":"Hui\u2010Chen","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela S.","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Huan 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