{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:37:51Z","timestamp":1776703071816,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Hyperglycemia and an increased ventilatory demand secondary to an increased CO<jats:sub>2<\/jats:sub> production are frequent undesirable effects of total parenteral nutrition (TPN) in critically ill patients. This study was performed to assess whether sodium lactate as a metabolic substrate may affect these variables. <jats:italic>Methods:<\/jats:italic> Five male patients with multiple trauma during the flow phase were studied during two consecutive 3\u2010hour periods of isocaloric (1.1 x resting energy expenditure) TPN. Sixty\u2010five percent of total calories was provided as carbohydrate, 15% as lipids, and 20% as amino acids during the first period (TPN\u2010glucose), whereas 35% carbohydrate, 30% lactate, 20% lipids, and 15% amino acids (TPN\u2010lactate) were substituted during the second period. Respiratory gas exchanges and net substrate oxidation were assessed by means of indirect calorimetry. Glucose kinetics was determined by primed\u2010constant infusion of U\u2010<jats:sup>13<\/jats:sup>C glucose. <jats:italic>Results:<\/jats:italic> Compared with TPN\u2010glucose, TPN\u2010lactate decreased glycemia by 20%, insulinemia by 43%, net carbohydrate oxidation (assessed from indirect calorimetry) by 34%, and plasma glucose oxidation (assessed from <jats:sup>13<\/jats:sup>CO<jats:sub>2<\/jats:sub>) by 54%. Respiratory oxygen exchanges were increased by 3.7% due to a 20% thermic effect of lactate, but respiratory CO<jats:sub>2<\/jats:sub> exchanges did not change. Pao<jats:sub>2<\/jats:sub> decreased by 11.3 mm Hg, indicating that the increased O<jats:sub>2<\/jats:sub> consumption was not matched by an appropriate increase in spontaneous ventilation. Arterial pH increased from 7.41 \u00b1 0.04 to 7.46 \u00b1 0.05. <jats:italic>Conclusion:<\/jats:italic> Sodium lactate as a metabolic substrate limits hyperglycemia but induces metabolic alkalosis and does not spare the ventilatory demand. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>20<\/jats:bold>:257\u2013263, 1996)<\/jats:p>","DOI":"10.1177\/0148607196020004257","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"257-263","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic and Respiratory Effects of Sodium Lactate During Short IV Nutrition in Critically III 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