{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:16:32Z","timestamp":1781057792909,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> By using undenatured purified albumin preparations radiolabeled with iodine, the half\u2010life of serum albumin in well patients who are stable is known to be approximately 17 days. However, when a patient is suffering with an acute illness such as sepsis, trauma, burns or after an extensive operative procedure, the serum albumin level decreases. It is not known whether this fall in serum albumin is due to increased catabolism, decreased synthesis, or a combination of both factors. This study explores the kinetics of albumin catabolism under these circumstances to clarify the issue. <jats:italic>Methods:<\/jats:italic> <jats:sup>125<\/jats:sup>I\u2010labeled albumin was administered intravenously to 10 critically ill, hypoalbuminemic patients receiving total parenteral nutrition (TPN). Each subject had frequent blood samples taken for at least 10 days to measure the decline of plasma radioactivity over time. None was receiving unlabeled albumin during the investigation. It was assumed that the plasma decay would follow first\u2010order kinetics after the early equilibration phase. Radioactivity of heparinized blood samples (counts\/2 mL sample) were counted and the results were graphically expressed. <jats:italic>Results:<\/jats:italic> One subject was not evaluated because he was discharged on the 8th day. The APACHE (acute physiology and chronic health evaluation) score for the other nine subjects ranged from 4 to 18 (mean, 7.5). The serum albumin remained below 3.0 g\/dL in each subject and did not change statistically throughout the study. The radioiodinated albumin half\u2010life ranged from 5.52 to 11.76 days (mean 9.10 days; compared with published normal of approximately 17 days). The equilibration time was 3 to 7 days. The average albumin catabolized for this group is similar to previously reported normal subjects, 0.18 g\/kg\/d. <jats:italic>Conclusion:<\/jats:italic> Hypoalbuminemic patients receiving TPN have markedly shortened plasma albumin half\u2010lives, but the albumin catabolized per day is similar to normal patients. These data argue for both a synthetic and catabolic defect that explains the hypoalbuminemia in this patient group. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>20:<\/jats:bold>424\u2013428, 1996)<\/jats:p>","DOI":"10.1177\/0148607196020006424","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"424-428","source":"Crossref","is-referenced-by-count":29,"title":["Albumin Kinetics in Hypoalbuminemic Patients Receiving Total Parenteral Nutrition"],"prefix":"10.1002","volume":"20","author":[{"given":"Anita","family":"Spiess","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Mikalunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1996,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"426","article-title":"Rapid miniaturized chromatographic quality control procedures for iodinated radiopharmaceuticals","volume":"35","author":"Zimmer AM","year":"1978","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102789"},{"key":"e_1_2_1_4_1","first-page":"181","article-title":"The utility of serum albumin values in the nutritional assessment of hospitalized patients","volume":"57","author":"Anderson CF","year":"1982","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90248-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718000400404"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198205000-00003"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.10.2013"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198403000-00009"},{"key":"e_1_2_1_10_1","first-page":"300","article-title":"Koretz R: Serum albumin as a marker of nutrition","volume":"19","author":"Karlawish J.","year":"1994","journal-title":"J Clin Gastroent"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198908000-00004"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.5.0668"},{"key":"e_1_2_1_13_1","first-page":"340","article-title":"The significance of hypoalbuminemia following injury and infection","volume":"51","author":"Dahn MS","year":"1985","journal-title":"Am Surg"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103184"},{"key":"e_1_2_1_15_1","first-page":"255","volume-title":"Albumin Structure, Function and Uses","author":"Waldmann TA","year":"1970"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102542"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365515909060447"},{"key":"e_1_2_1_18_1","first-page":"708","article-title":"Bestemmelse af albuminomsaetningen med 131\u2010J\u2010maerket albumin. Metoder til beregning af albuminomsaetningen og nogle kliniske vigtige anvendelsesomrader","volume":"63","author":"Jarnum S.","year":"1960","journal-title":"Nord Med"},{"key":"e_1_2_1_19_1","first-page":"904","article-title":"Differences in daily albumin synthesis between normal men and women as measured with 131\u2010I\u2010labelled albumin","volume":"55","author":"Steinfeld JL","year":"1960","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_20_1","first-page":"161","article-title":"Metabolism of 131\u2010I\u2010labelled albumin","volume":"20","author":"Cohen S.","year":"1961","journal-title":"Clin Sci"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104594"},{"key":"e_1_2_1_22_1","first-page":"183","article-title":"Studies of the metabolism and distribution of albumin with autologous I\u2010131\u2010albumin in healthy men","volume":"61","author":"Takeda Y.","year":"1963","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_23_1","first-page":"593","article-title":"The normal metabolism of 131\u2010I\u2010labelled albumin in man","volume":"33","author":"Rossing N.","year":"1967","journal-title":"Clin Sci"},{"key":"e_1_2_1_24_1","first-page":"281","article-title":"Serum albumin turnover in normal subjects and patients with cirrhosis measured by 131\u2010I\u2010labelled albumin","volume":"25","author":"Wilkinson P.","year":"1963","journal-title":"Clin Sci"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1962.tb07141.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195807000-00009"},{"key":"e_1_2_1_27_1","first-page":"343","article-title":"Disappearance curve of intravenously administered I\u2010131\u2010tagged albumin in the postoperative injury reaction","volume":"4","author":"Sterling K.","year":"1955","journal-title":"Metabolism"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105319"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607196020006424","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607196020006424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:21:43Z","timestamp":1760638903000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607196020006424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1177\/0148607196020006424"],"URL":"https:\/\/doi.org\/10.1177\/0148607196020006424","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}