{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:26:44Z","timestamp":1760660804412,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> This study was undertaken to elucidate the specific effects of short\u2010term artificial nutrition on human liver protein metabolism. <jats:italic>Methods:<\/jats:italic> Thirty patients undergoing elective laparoscopic cholecystectomy were studied: a control group (n = 16) and a group that received total parenteral nutrition (TPN; n = 14). The nutrition consisted of a balanced IV solution of nutrients (17.5 nonprotein kcal\/kg body wt, 50% fat, 50% carbohydrates, and 0.1 gN\/kg) that was discontinued when the investigation was finished, after a total infusion time of 8.6 \u00b1 1.0 hours. A liver biopsy specimen was taken as soon as possible after surgery was started, for the determination of the free hepatic amino acid concentrations. In 16 of the patients, L\u2010[<jats:sup>2<\/jats:sup>H<jats:sub>5<\/jats:sub>]phenylalanine was given by IV to determine the fractional synthesis rate of total liver protein in a second liver biopsy specimen taken approximately 30 minutes later. Results: The fractional synthesis rate of total liver protein was 15.2% \u00b1 4.7%\/d in the TPN group (n = 7), which was not different from that of the control group (17.7% \u00b1 3.8%\/d, n = 9). However, the free hepatic concentrations of alanine (p &lt;.05) and the essential amino acids increased (p &lt;.001) in the TPN group, whereas the total hepatic amino acid concentrations were comparable between the groups. <jats:italic>Conclusion:<\/jats:italic> Thus short\u2010term TPN induced specific changes of the free hepatic amino acid concentrations, whereas total liver protein synthesis remained unaffected by the nutrition. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> 21:330\u2013335, 1997)<\/jats:p>","DOI":"10.1177\/0148607197021006330","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"330-335","source":"Crossref","is-referenced-by-count":13,"title":["The Effects of Short\u2010Term Parenteral Nutrition on Human Liver Protein and Amino Acid Metabolism During Laparoscopic 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