{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:27:22Z","timestamp":1760660842701,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> The aim of this work was to study the serum bioavailability of glucose and alanine after bolus injection into the peritoneal cavity in Wistar rats and to determine the influence of their metabolism on the rate of absorption of these nutrients. <jats:italic>Methods:<\/jats:italic> A group of animals (n = 14) was infused intraperitoneally (IP) or IV with 2 \u03bcCi of nonmetabolizable L\u2010[1\u2010<jats:sup>14<\/jats:sup>C]glucose diluted in 5 mL of 5% D\u2010glucose\/250 g body wt, after which plasma radioactivity was determined. A second group of animals (n = 14) received, either IP or IV, 3 \u03bcCi of nonmetabolizable D\u2010[U\u2010<jats:sup>14<\/jats:sup>C]alanine diluted in 2 mL of an iso\u2010osmolar L\u2010amino acid solution\/250 g body wt, after which both plasma radioactivity and L\u2010alanine concentration were determined. The constants of absorption from peritoneal cavity (<jats:italic>K<\/jats:italic> <jats:sub>a<\/jats:sub>) and elimination from plasma (<jats:italic>K<\/jats:italic> <jats:sub>e<\/jats:sub>) and the serum absolute bioavailability <jats:italic>BA<\/jats:italic> <jats:sub>a<\/jats:sub>) after 8 h were calculated assuming a bicompartment pharmacokinetic model. <jats:italic>Results:<\/jats:italic> L\u2010glucose: <jats:italic>K<\/jats:italic> <jats:sub>a<\/jats:sub> = 3.05 \u00b1 0.97 h<jats:sup>\u22121<\/jats:sup>; <jats:italic>K<\/jats:italic> <jats:sub>e<\/jats:sub> = 0.40 \u00b1 0.12 h<jats:sup>\u22121<\/jats:sup>; <jats:italic>BA<\/jats:italic> <jats:sub>a<\/jats:sub> = 94% \u00b1 4%. D\u2010alanine: <jats:italic>K<\/jats:italic> <jats:sub>a<\/jats:sub> = 1.08 \u00b1 0.40 h<jats:sup>\u22121<\/jats:sup>; <jats:italic>K<\/jats:italic> <jats:sub>e<\/jats:sub> = 0.11 \u00b1 0.06 h<jats:sup>\u22121<\/jats:sup>; <jats:italic>BA<\/jats:italic> <jats:sub>a<\/jats:sub> = 90% \u00b1 11%. L alanine: <jats:italic>K<\/jats:italic> <jats:sub>a<\/jats:sub> = 1.75 \u00b1 0.273 h<jats:sup>\u22121<\/jats:sup>; <jats:italic>K<\/jats:italic> <jats:sub>e<\/jats:sub> = 0.02 \u00b1 0.01 h<jats:sup>\u22121<\/jats:sup>; <jats:italic>BA<\/jats:italic> <jats:sub>a<\/jats:sub> = 99% \u00b1 1%. No hyperglycemia, hypoglycemia, or glycosuria appeared in any case. <jats:italic>Conclusions:<\/jats:italic> The absorption rate from peritoneal cavity is nearly 10\u2010fold higher than the elimination rate from plasma for the three substrates. Eight hours after IP injection an abso lute bioavailability almost as high as after IV injection (ie, close to 100%) was achieved. The metabolism of the nutrients seems to help the peritoneal absorption, as L\u2010alanine is better absorbec then D\u2010alanine. These results show that upon IP injection the stud ied nutrients are almost completely absorbed in a short period of time without hyperglycemia or neoglucogenesis and so sug gest that their administration may be a feasible approach to feed ing patients receiving peritoneal dialysis. This model could be applied to other compounds, such as peptides and disaccharides <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>22<\/jats:bold>:72\u201376, 1998)<\/jats:p>","DOI":"10.1177\/014860719802200272","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"72-76","source":"Crossref","is-referenced-by-count":2,"title":["A Pharmacokinetic Study of Peritoneal Absorption of Glucose and Alanine in Rats: Nutritional Implications"],"prefix":"10.1002","volume":"22","author":[{"given":"J.M.","family":"Mor\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mahedero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mari\u00f1\u00f5","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Vinagre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000690305"},{"key":"e_1_2_1_3_1","first-page":"98","article-title":"Automated peritoneal dialysis : Analysis of several methods of peritoneal dialysis","volume":"112","author":"Miller JH","year":"1966","journal-title":"Trans Am Soc Artif Inter Organs"},{"key":"e_1_2_1_4_1","first-page":"148","article-title":"In vitro simulation of peritoneal dialysis","volume":"96","author":"McGary T\u2010J.","year":"1987","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1152\/physrev.1953.33.3.387","article-title":"Passage of molecules through capillary walls","volume":"33","author":"Pappenheimer JR","year":"1953","journal-title":"Physiol Rev"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/089686088300300206","article-title":"Effective use of amino acid dialysate over four weeks in CAPD patients","volume":"3","author":"Oren A.","year":"1983","journal-title":"Perit Dial Bull"},{"key":"e_1_2_1_7_1","first-page":"93","article-title":"Systemic appearance of nutrients used in peritoneal nutritional support [Abstr]","volume":"8","author":"Selby RB","year":"1984","journal-title":"JPEN"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1984.01390230019004"},{"key":"e_1_2_1_9_1","first-page":"1","article-title":"Long\u2010term peritoneal nutrition in dogs: Metabolic and histopathological results","volume":"5","author":"Mor\u00e1n JM","year":"1989","journal-title":"Nutrition"},{"key":"e_1_2_1_10_1","first-page":"251","article-title":"Absorption of amino acids and fat from the peritoneum","volume":"13","author":"Gjessing J.","year":"1968","journal-title":"Opusc Med"},{"key":"e_1_2_1_11_1","first-page":"1","article-title":"Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer","volume":"62","author":"Dedrick RL","year":"1968","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_12_1","first-page":"219","article-title":"Method of GOD for glucose analysis","volume":"252","author":"Werner W.","year":"1970","journal-title":"Anal Chem"},{"key":"e_1_2_1_13_1","first-page":"1679","volume-title":"L\u2010Alanine. 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IN Methods of Enzymatic Analysis","author":"Williamson DH","year":"1979"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600650713"},{"key":"e_1_2_1_15_1","first-page":"335","article-title":"Discrimination of kinetic models in heteroscedastic parametric estimation of bentazepam following multiple dosing","volume":"26","author":"Fern\u00e1ndez Lastra C.","year":"1988","journal-title":"Int J Clin Pharmacol Ther Toxicol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197004000-00005"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198203183061101"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010006604"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136874"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1987.01400150098019"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80644-0"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860719802200272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:52:37Z","timestamp":1760629957000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860719802200272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1177\/014860719802200272"],"URL":"https:\/\/doi.org\/10.1177\/014860719802200272","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}