{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:18:38Z","timestamp":1763036318269,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Malnutrition is a frequent problem of patients on intermittent hemodialysis and substantially contributes to their morbidity and mortality. Methods: In 26 hemodialysis patients who, despite dietary advice and oral nutritional supplements, still had malnutrition, the feasibility and effects of a specific intradialytic parenteral nutritional (IPN) regimen were evaluated during a 9\u2010month study period. An IPN solution consisting of 250 mL glucose 50%, 250 mL lipids 20%, and 250 mL amino acids 7% was infused IV three times a week during the dialysis session. At the end of each dialysis session an additional volume of 250 mL amino acids was infused as a rinsing fluid. Insulin was administered IV before dialysis. Results: Of the 26 enrolled patients, 16 completed the study. The remaining 10 patients withdrew mainly because of muscle cramps and nausea during the initiation phase of the treatment, when sodium was not present in the IPN fluid but was supplemented intermittently. In the 16 treated patients, body weight, which had decreased in the pretreatment period from 58.2 \u00b1 1.3 kg (\u20106 months) to 54.8 \u00b1 10.1 kg at the start of the study, increased again up to 57.1 \u00b1 10.7 kg after 9 months IPN (p &lt;.05). Serum transferrin and prealbumin rose from 1.7 \u00b1 0.4 to 2.0 \u00b1 0.4 g\/L and from 0.23 \u00b1 0.05 to 0.27 \u00b1 0.10 g\/L, respectively. Bone densitometry showed an increase of tissue mass, mostly related to a rise in fat tissue. Triceps skinfold (p &lt;.05) and arm muscle compartment of the midarm (p =.07) increased as well. No such changes were observed in the patients who withdrew from treatment. Conclusions: An IV hyperalimentation regimen applied to malnourished hemodialysis patients results in a rise of body weight and in a limited, but significant, change of some parameters of nutritional status. The rise in body weight is at least in part attributable to an increase of body fat, without changes in plasma lipid levels. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>23:<\/jats:bold>90\u201395, 1999)<\/jats:p>","DOI":"10.1177\/014860719902300290","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"90-95","source":"Crossref","is-referenced-by-count":52,"title":["Intradialytic Parenteral Nutrition in Malnourished Hemodialysis Patients: A Prospective Long\u2010Term Study"],"prefix":"10.1002","volume":"23","author":[{"given":"Anna Katharina","family":"Mortelmans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Duym","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Vandenbroucke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"De Smet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke","family":"Dhondt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"Lesaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Ir","given":"Hans","family":"Verwimp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Vanholder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"457","article-title":"Nutritive hemodialysis in renal failure","volume":"17","author":"Quarto di Palo F.","year":"1978","journal-title":"Dial Transplant"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1525-139X.1992.tb00134.x","article-title":"Nutritional management of the chronic hemodialysis patient","volume":"5","author":"Owen WF","year":"1992","journal-title":"Sem Dial"},{"key":"e_1_2_1_4_1","first-page":"551","article-title":"Intradialytic parenteral nutrition","volume":"9","author":"Skeie B.","year":"1991","journal-title":"Dial Transplant"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1978.11714977"},{"key":"e_1_2_1_6_1","first-page":"1810","article-title":"Malnutrition is lethal, diagnosable, and treatable in ESRD patients","volume":"23","author":"Kaminski MV","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81083-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81075-4"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90494-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01419.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000182627"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/ajcn\/39.4.547","article-title":"Nutritional status and lymphocyte function in maintenance hemodialysis patients","volume":"37","author":"Wolfson M.","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-1087-4_53"},{"key":"e_1_2_1_14_1","first-page":"1411","article-title":"Intradialytic parenteral nutrition in malnourished patients on chronic haemodialysis therapy","volume":"10","author":"Smolle KH","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/ajcn\/52.4.726","article-title":"Intradialytic parenteral nutrition with lipids and amino acids in malnourished hemodialysis patients","volume":"52","author":"Cano N.","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_16_1","first-page":"M373","article-title":"Intradialytic parenteral nutrition in chronic hemodialysis patients","volume":"37","author":"Snyder S.","year":"1991","journal-title":"ASAIO Trans"},{"key":"e_1_2_1_17_1","first-page":"495","article-title":"Intradialytic parenteral nutrition administration during outpatient hemodialysis","volume":"16","author":"Olshan AR","year":"1987","journal-title":"Dial Transplant"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80134-X"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90181-7"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.78"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.339"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117208"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.187"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110067"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111765"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607185009006709"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)70364-5"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/ajcn\/32.3.693","article-title":"A radiographic method of quantifying protein\u2010calorie undernutrition","volume":"32","author":"Heymsfield SB","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/014860717700100101","article-title":"Nutritional and metabolic assessment of the hospitalized patient","volume":"1","author":"Blackburn G.","year":"1977","journal-title":"JPEN"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/ajcn\/43.6.946","article-title":"\u2010H: Nutritional status of maintenance hemodialysis patients","volume":"43","author":"Carvounis CP","year":"1986","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/ajcn\/65.5.1384","article-title":"Growth hormone or insulin\u2010like growth factor 1 increases fat oxidation and decreases protein oxidation without altering energy expenditure in parenterally fed rats","volume":"65","author":"Lo H\u2010C.","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80399-4"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860719902300290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:12:29Z","timestamp":1760627549000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860719902300290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["10.1177\/014860719902300290"],"URL":"https:\/\/doi.org\/10.1177\/014860719902300290","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}