{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:19:22Z","timestamp":1791029962748,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Some clinical studies report the effects of parenteral nutrition in malnourished cancer patients, but few discuss the tumor response to parenteral nutrition plus chemotherapy. If used in combination, the antitumor activity of chemotherapeutic agents may compensate for the tumor stimulation of parenteral nutrition. <jats:italic>Methods:<\/jats:italic> Ninety\u2010two patients with operable gastrointestinal cancer and malnutrition were randomly assigned to four interventions that were administered for 7 days preoperatively : parenteral nutrition alone, parenteral nutrition plus chemotherapy, chemotherapy alone, or no treatment (control). The preintervention and postintervention DNA content, DNA index, percentage of cells in S phase, and tumor cell sensitivity to chemotherapy were measured using image cytometry. <jats:italic>Results:<\/jats:italic> Parenteral nutrition resulted in a significant proliferation of tumor cells and a significant increase in the sensitivity of tumor cells to chemotherapy; these effects were not seen in tumors of patients receiving parenteral nutrition plus chemotherapy. There was, however, a nonsignificant increase in tumor cell proliferation and sensitivity to chemotherapy in the tumors of subjects receiving combined therapy compared with those of subjects who received chemotherapy alone. The postintervention nutritional status of both the parenteral nutrition group and the parenteral nutrition plus chemotherapy group were significantly better than that of the control group and the chemotherapy group. The short\u2010term, postoperative clinical outcomes in the chemotherapy group were significantly worse than those in the other three groups. <jats:italic>Conclusions:<\/jats:italic> These results indicate that combining chemotherapy and nutrition support preoperatively for malnourished patients with gastrointestinal cancer improves short\u2010term nutritional status without increasing the proliferation of tumor cells and prevents the postoperative complications that occur when such patients are given chemotherapy without nutrition support. The results also suggest\u2014but do not prove\u2014that parenteral nutrition may increase the effectiveness of chemotherapy in malnourished patients. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> 23:237\u2013241, 1999)<\/jats:p>","DOI":"10.1177\/0148607199023004237","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"237-241","source":"Crossref","is-referenced-by-count":35,"title":["Effects of Parenteral Nutrition Support and Chemotherapy on the Phasic Composition of Tumor Cells in Gastrointestinal Cancer"],"prefix":"10.1002","volume":"23","author":[{"given":"Dayong","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie 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