{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:27:52Z","timestamp":1793021272341,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","issue":"5S","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1999,9]]},"abstract":"<jats:p>Purpose: To evaluate the impact of alanyl\u2010glutamine (Ala\u2010Gln)\u2010supplemented parenteral nutrition (PN) on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients. Methods: One hundred twenty patients undergoing major abdominal surgery were enrolled. Protocol was approved and informed consent obtained. A double\u2010blind protocol was designed as used in Europe. The clinical safety and outcome were observed for 60 patients in 2 centers (30 each). Sixty patients from 2 additional centers (30 each) were observed for clinical safety, nitrogen balance, intestinal permeability, and clinical outcome. All patients received isonitrogenous (0.20 g\/kg body wt per day) and isocaloric (30 kcal\/kg body wt per day) parenteral nutrition. The study group received Ala\u2010Gln (Dipeptiven, Fresenius Kabi, Bad Homberg, Germany) 0.50 g\/kg per day. Clinical chemistry variables, plasma amino acids profile, nitrogen balance, intestinal permeability (lactulose\/mannitol ratio [L\/M ratio]) were measured; hospital stay and infection rate were monitored. Statview was used for analysis of variance (ANOVA) or \u03c7 2 tests. Data were expressed as means \u00b1 SD, and the significance level was p &lt;.05. Results: The patients in both groups were comparable prior to the operation. Vital signs and clinical chemical parameters were similar between groups. L\/M ratio was 0.047 \u00b1 0.029 in control and 0.058 \u00b1 0.049 in study group before the operation (AOD\u20103). The L\/M ratio was 0.132 \u00b1 0.081 in the control group, and 0.097 \u00b1 0.063 in study group on the seventh postoperative day. The difference of L\/M ratio between groups was significant (p =.02). The cumulative nitrogen balance values were \u20105 \u00b1 162 mg\/kg for 6 days in control and 144 \u00b1 145 mg\/kg for 6 days in study group (p =.0004). All the patients recovered without incision infection. However, there were 3 cases that had infection\u2010related complications in the control group; the difference was not significant between groups. The hospital stay in the study group was 12.5 days, which was 4 days less than that of the control group (p =.02). Conclusions: Ala\u2010Gln\u2010supplemented PN was clinically safe, had better nitrogen balance, and maintained intestinal permeability in postoperative patients. The clinical outcome of the patients in study group was better; it was significantly different from the control group. (Journal of Parenteral and Enteral Nutrition 23:S62\u2010S66, 1999)<\/jats:p>","DOI":"10.1177\/014860719902300516","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T15:14:54Z","timestamp":1253027694000},"source":"Crossref","is-referenced-by-count":63,"title":["The Impact of Alanyl\u2010Glutamine on Clinical Safety, Nitrogen Balance, Intestinal Permeability, and Clinical Outcome in Postoperative Patients: A Randomized, Double\u2010Blind, Controlled Study of 120 Patients"],"prefix":"10.1002","volume":"23","author":[{"family":"Zhu Ming Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.G.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.X.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.R.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.W.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,9]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"The Ultimate Nutrient Glutamine","year":"1994"},{"key":"e_1_2_1_3_1","first-page":"31","article-title":"Glutamine infusion supports amino acid metabolism during stimulated stress","volume":"43","year":"1986","journal-title":"Curr Surg"},{"key":"e_1_2_1_4_1","first-page":"231","article-title":"Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199011000-00012"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90939-E"},{"key":"e_1_2_1_7_1","article-title":"Statistical Software","year":"1994","journal-title":"Statistical Lectures of An Hui Medical School"},{"key":"e_1_2_1_8_1","volume-title":"Abacus Concepts","year":"1992"},{"key":"e_1_2_1_9_1","first-page":"793","article-title":"Effect of alanyl\u2010glutamine on gut barrier function","volume":"12","year":"1996","journal-title":"Basic Nutr Invest"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607193017002134"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860719902300516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:48:48Z","timestamp":1760640528000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860719902300516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":9,"journal-issue":{"issue":"5S","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["10.1177\/014860719902300516"],"URL":"https:\/\/doi.org\/10.1177\/014860719902300516","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}