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Since the palpation is subjective in nature, a method using ultrasound for detection of the differential motion associated with hard lesions is proposed. It is intended that regions of detected \u2018lump\u2019 be highlighted on top of a conventional B-mode image so that the user can positively associate palpated lumps with specific regions on the anatomical B-mode image. We detect the differential motion associated with a lesion by detecting a local abnormality in a map of image-to-image correlations as the transducer is swept in an elevational direction. Experiments were performed with three different tissue mimicking phantoms. The results indicate that the location of the mobile lesion can be successfully estimated whereas immobile lesions are not very detectable. This approach is simple and requires only a short period of time for each scan. It has practically no theoretical incremental cost.<\/jats:p>","DOI":"10.1177\/016173460302500402","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T02:14:01Z","timestamp":1362190441000},"page":"226-244","source":"Crossref","is-referenced-by-count":0,"title":["Detection of Lesions Using Differential Rates of Speckle Decorrelation"],"prefix":"10.1177","volume":"25","author":[{"given":"Jun S.","family":"Ha","sequence":"first","affiliation":[{"name":"Biomedical Engineering Department University of Virginia Room 2121, MR-5 Building 415 Lane Rd. Charlottesville, VA 22908-0759"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Hossack","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department University of Virginia Room 2121, MR-5 Building 415 Lane Rd. 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