{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:54:37Z","timestamp":1777913677064,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ultrason Imaging"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Our paper presents the ultrasound (US) patterns of a rare kidney disease\u2014medullary sponge kidney (MSK)\u2014that have not been described before in comparison with other causes of medullary hyperechogenicity and correlates them with the severity of the disease and prognosis. This is a clinical observational study of all US examinations in the Nephrology Department over a period of 6 years. The abdominal US focused on the kidneys was recorded. US characteristics of the medulla and cortex were analyzed. We found 10 patients with characteristic daisy flower (DF) kidneys. Positive diagnosis in association with other renal risk factors, prognosis, and evolution were evaluated. Two patterns of medullary hyperechogenicity were found and were correlated with disease severity and kidney function. The first pattern is a homogenous echogenicity of the medulla described as a \u201cdaisy-like\u201d appearance. The second pattern: calcifications associated with medullar echogenicity, stone production, nephrocalcinosis, and impaired kidney function: \u201catypical daisy-like.\u201d Medullary hyperechogenicity can have more US patterns. In MSK, if the medullary echogenicity is homogenous the evolution is benign, whereas the second, inhomogeneous pattern, has a variable clinical presentation with nephrocalcinosis and the outcome is more severe, leading to chronic kidney disease and impairing the quality of life.<\/jats:p>","DOI":"10.1177\/01617346231165493","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T04:04:01Z","timestamp":1681445041000},"page":"151-155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound Patterns and Disease Progression in Medullary Sponge Kidney in Adults"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-3942","authenticated-orcid":false,"given":"Mirela Liana","family":"Gliga","sequence":"first","affiliation":[{"name":"Nephrology Department, Mures Clinical County Hospital, Targu Mures, Romania"},{"name":"George Emil Palade University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania"},{"name":"Diaverum Dialysis Center, Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-9117","authenticated-orcid":false,"given":"Cristian","family":"Chirila","sequence":"additional","affiliation":[{"name":"Nephrology Department, Mures Clinical County Hospital, Targu Mures, Romania"},{"name":"George Emil Palade University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Maria","family":"Chirila","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Mures Clinical County Hospital, Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"bibr1-01617346231165493","unstructured":"Garfield K, Leslie SW. Medullary Sponge Kidney. StatPearls, February 2021, https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470220\/"},{"key":"bibr2-01617346231165493","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.09.035"},{"key":"bibr3-01617346231165493","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.378"},{"key":"bibr4-01617346231165493","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2747"},{"key":"bibr5-01617346231165493","doi-asserted-by":"publisher","DOI":"10.11152\/mu-2689"},{"key":"bibr6-01617346231165493","doi-asserted-by":"publisher","DOI":"10.11152\/mu-984"},{"key":"bibr7-01617346231165493","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02084-1"},{"key":"bibr8-01617346231165493","doi-asserted-by":"publisher","DOI":"10.1159\/000099350"},{"key":"bibr9-01617346231165493","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2010.19.15.77693"},{"key":"bibr10-01617346231165493","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0480-8"},{"issue":"1","key":"bibr11-01617346231165493","volume":"14","author":"Gliga M","year":"2012","journal-title":"Med Ultrason"},{"key":"bibr12-01617346231165493","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02360409"},{"issue":"10","key":"bibr13-01617346231165493","volume":"55","author":"Hong Y","year":"2017","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"bibr14-01617346231165493","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.155.2.2115256"}],"container-title":["Ultrasonic Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01617346231165493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01617346231165493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01617346231165493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:28:59Z","timestamp":1777652939000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01617346231165493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,14]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/01617346231165493"],"URL":"https:\/\/doi.org\/10.1177\/01617346231165493","relation":{},"ISSN":["0161-7346","1096-0910"],"issn-type":[{"value":"0161-7346","type":"print"},{"value":"1096-0910","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,14]]}}}