{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:40:35Z","timestamp":1788964835109,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ultrason Imaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>To investigate the efficiency of contrast-enhanced ultrasound (CEUS) features, particularly ring-enhancement patterns, in the differential diagnosis of thyroid nodules. 302 nodules with CEUS ring-enhancement were retrospectively enrolled, including 135 benign and 167 malignant ones. The ring-enhancement patterns were classified into regular and irregular hyper- or hypo-ring enhancement. Comparative analyses of ultrasound (US) and CEUS features between benign and malignant nodules were performed. The diagnostic performances of the ring-enhancement patterns and Chinese Thyroid Imaging Reporting and Data System (C-TIRADS) were compared in nodules with different sizes. Irregular hypo-ring enhancement was much more common in malignancies than that in benign ones, and it was an independent predictor for thyroid malignant nodules. With irregular hypo-ring enhancement as the diagnostic criteria for malignant nodules, the specificity was higher than that of C-TIRADS (85.2% vs. 75.6%, p\u2009=\u2009.037) while the AUC was comparable (0.845 vs. 0.803, p\u2009=\u2009.136) in all nodules. When the nodule size was taken into account, the specificity and AUC were both significantly higher than those of C-TIRADS (92.8% vs. 81.1%, p\u2009=\u2009.021; 0.907 vs. 0.823, p\u2009=\u2009.026) in nodules\u2009\u226510\u2009mm, which can decrease the unnecessary FNA rate. Irregular hypo-ring enhancement was a valuable CEUS feature for the differential diagnosis of thyroid nodules, especially in nodules\u2009\u226510\u2009mm.<\/jats:p>","DOI":"10.1177\/01617346241291511","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T02:10:09Z","timestamp":1729476609000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Ring-Enhancement on CEUS: Is it Useful in the Differential Diagnosis of Solid Thyroid Nodules?"],"prefix":"10.1177","volume":"47","author":[{"given":"Tingting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hantao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-7021","authenticated-orcid":false,"given":"Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, Fujian, China"},{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,20]]},"reference":[{"key":"bibr1-01617346241291511","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02162.x"},{"key":"bibr2-01617346241291511","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"bibr3-01617346241291511","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.03.009"},{"key":"bibr4-01617346241291511","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2021.0713"},{"key":"bibr5-01617346241291511","doi-asserted-by":"publisher","DOI":"10.1159\/000478927"},{"key":"bibr6-01617346241291511","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"key":"bibr7-01617346241291511","doi-asserted-by":"crossref","unstructured":"Zhou J, Yin L, Wei X, Zhang S, Song Y, Luo B, et al. 2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS. 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