{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:47:09Z","timestamp":1789753629704,"version":"4.0.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81972423"],"award-info":[{"award-number":["81972423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202262"],"award-info":[{"award-number":["82202262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medicine Plus Program of Shenzhen University under Grant","award":["2024YG007"],"award-info":[{"award-number":["2024YG007"]}]},{"name":"Shenzhen Engineering Research Center of Multi- Modal Fusion Medical Intelligent Diagnosis Technology","award":["XMHT20220104016"],"award-info":[{"award-number":["XMHT20220104016"]}]},{"name":"General Project of Science and Technology Innovation Committee of Shenzhen","award":["JCYJ20220530154600001"],"award-info":[{"award-number":["JCYJ20220530154600001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ultrason Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>\n                    This study aims to establish and validate an ultrasound radiomics nomogram for preoperative prediction of central lymph node metastasis in papillary thyroid microcarcinoma (PTMC) before operation. A retrospective analysis conducted on ultrasonic images and clinical features derived from 288 PTMC patients, who were divided into training cohorts (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009201) and validating cohorts (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200987) in a ratio of 7:3 base on the principle of random allocation. Radiomics features were extracted from the PTMC patients after ultrasonic examination, followed by dimension reduction and characteristic selection to construct the radiomics score (Radscore) using LASSO regression analysis. Subsequently, the models, ultrasound features plus clinical features (US-Clin), radiomics score model, and combined model of clinical features plus ultrasound features and Radscore (Combined-model) were built through multi-factor logistic regression analysis. After that, the nomograms were developed for visualization and presentation of these models. The discriminative power, calibration and clinical utility of the nomogram models were evaluated in the training and validating cohorts. The Radscore model comprised 12 carefully selected features. The independent risk factors for conventional ultrasound features and clinical features of PTMC in predicting CLNM included age &lt;45\u2009years, tumor envelope invasion, male gender and presence of microcalcifications, while the enhanced ultrasound features risk factor was extrathyroidal expansion. The combined model showed good performance in predicting PTMC CLNM, with AUCs of 0.921 and 0.889 in the training and validating cohorts, respectively. And DCA based on the prediction model showed good clinical utility. The nomogram developed based on preoperative clinical data, ultrasound features, and Radscore of PTMC patients can more accurately predict central lymph node metastasis (CLNM) in PTMC patients. However, it needs to be validated for clinical applicability in multicenter studies with larger sample sizes and combined with genomic mutation analyses of the tumors.\n                  <\/jats:p>","DOI":"10.1177\/01617346251313982","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:18:55Z","timestamp":1738156735000},"page":"93-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The Predictive Value of a Nomogram Based on Ultrasound Radiomics, Clinical Factors, and Enhanced Ultrasound Features for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma"],"prefix":"10.1177","volume":"47","author":[{"given":"Lei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Yue","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Hospital, Southern Medical University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-6338","authenticated-orcid":false,"given":"Dongmei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijian","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Shenzhen Nanshan District Peoples Hospital, Shenzhen, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2966-0322","authenticated-orcid":false,"given":"Yi","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, South China Hospital, Medical School, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.10.007"},{"issue":"1","key":"e_1_3_3_3_2","article-title":"Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients","volume":"16","author":"Zheng X","year":"2019","unstructured":"Zheng X, Peng C, Gao M, Zhi J, Hou X, Zhao J, et al Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients. 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Chin Med Imag Technol. 2019;35(5):673-6.","journal-title":"Chin Med Imag Technol"},{"issue":"5","key":"e_1_3_3_9_2","article-title":"Ultrasonographical, clinical and histopathological features of 1264 nodules with papillary thyroid carcinoma and microcarcinoma based on tumor size","volume":"64","author":"Seyrek NC","year":"2021","unstructured":"Seyrek NC, Baser H, Topaloglu O, Ozdemir D, Kilicarslan A, Ersoy R, et al Ultrasonographical, clinical and histopathological features of 1264 nodules with papillary thyroid carcinoma and microcarcinoma based on tumor size. 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