{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:55:02Z","timestamp":1777913702560,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006599","name":"Focused Ultrasound Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ultrason Imaging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    Contrast-enhanced ultrasound (CEUS) shows promise in solid organ trauma by identifying areas of disrupted perfusion. In contrast, B-Flow ultrasound offers high fidelity imaging of larger vessels. We hypothesize that contrast-enhanced B-Flow (CEB-Flow) will improve accuracy of hepatic vessel injury delineation, as an adjunct tool to CEUS and future ultrasound-guided therapies. Imaging data was collected using our IACUC approved swine model for traumatic liver injury. All procedures were approved within this IACUC protocol. Sonography was performed using a Logiq E10 scanner with C1-6 probe (GE HealthCare). After ultrasound guided liver trauma, we performed open-abdomen B-Mode ultrasound, CEUS, and CEB-Flow of the injury during infusion of Definity (Lantheus Medical Imaging, N. Billerica, MA). CEUS was performed using coded harmonic imaging and CEB-Flow using a commercial package (GE Healthcare). Twelve swine were used for analysis. Three blinded interpreters were asked to identify injured liver parenchyma and lacerated vessels. Identification rates were compared using ultrasound-guided laceration images and pathology confirmation as a reference standard. Liver injury identification ranged from 88.3% to 100% on CEUS and 50%\u2009to\u200966.7% on CEB-Flow. Consensus identification rates in identifying parenchymal injury were not significantly different (91.7% CEUS vs. 66.7% CEB-Flow,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.25). Lacerated vessel identification ranged from 41.7%\u2009to\u200958.3% for CEUS and 75.0%\u2009to\u200991.7% for CEB-Flow. Specifically, CEB-Flow demonstrated improved consensus in identifying lacerated vasculature (41.7% CEUS vs. 91.7% CEB-Flow,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.041). In this swine model study, the combination of CEUS and CEB-Flow could accurately identify and localize traumatic hepatic injury. CEB-Flow may better characterize vessel injury, which in turn may direct and improve bedside management.\n                  <\/jats:p>","DOI":"10.1177\/01617346251346922","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T08:50:32Z","timestamp":1751532632000},"page":"182-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast-Enhanced B-Flow Ultrasound: A Novel Approach to Liver Trauma Imaging"],"prefix":"10.1177","volume":"47","author":[{"given":"Sriharsha","family":"Gummadi","sequence":"first","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Alnoury","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fari","family":"Fall","sequence":"additional","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Siu Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaizer","family":"Contreras","sequence":"additional","affiliation":[{"name":"Applied Physics Laboratory, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Applied Physics Laboratory, University of Washington, Seattle, WA, USA"},{"name":"Department of Biomedical Engineering and Mechanics, Virginia Tech University, Blacksburg, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Vlaisavljevich","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Mechanics, Virginia Tech University, Blacksburg, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne E.","family":"Wessner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-1371","authenticated-orcid":false,"given":"Flemming","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-3424","authenticated-orcid":false,"given":"John R.","family":"Eisenbrey","sequence":"additional","affiliation":[{"name":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00302-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004141"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-624X(97)00123-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1581-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2018.04.001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.230727"},{"key":"e_1_3_2_8_2","first-page":"39","article-title":"Emerging applications of contrast-enhanced ultrasound in trauma","volume":"2","author":"Tester B","year":"2022","unstructured":"Tester B, Liu JB, Eisenbrey JR, Koenig G. Emerging applications of contrast-enhanced ultrasound in trauma. Adv Ultrasound Diagn Ther. 2022;2:39-47.","journal-title":"Adv Ultrasound Diagn Ther"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-023-00771-4"},{"key":"e_1_3_2_10_2","unstructured":"Berger M Adams Q. B-Flow Technology. GE Healthcare; 2012. https:\/\/www.logiqclub.net\/club\/files\/news\/b-flow_technology_whitepaper.pdf. Accessed May 2025."},{"issue":"5","key":"e_1_3_2_11_2","article-title":"An innovative approach for preoperative perforator flap planning using contrast-enhanced B-flow imaging","volume":"9","author":"Heneweer C","year":"2021","unstructured":"Heneweer C, Zirk M, Safi A, Smeets R, Malter W, Kr\u00f6ger N, et al. An innovative approach for preoperative perforator flap planning using contrast-enhanced B-flow imaging. Plast Reconstr Surg Glob Open. 2021;9(5):e3547.","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2023.01.008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000004397"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000233762.49799.e0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.213303"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2024.3411795"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2024.3411795"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01670-z"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-025-01978-y"}],"container-title":["Ultrasonic Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01617346251346922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01617346251346922","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01617346251346922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:29:26Z","timestamp":1777652966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01617346251346922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1177\/01617346251346922"],"URL":"https:\/\/doi.org\/10.1177\/01617346251346922","relation":{},"ISSN":["0161-7346","1096-0910"],"issn-type":[{"value":"0161-7346","type":"print"},{"value":"1096-0910","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]}}}