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Analysis of image texture was performed on digitized video output from the ultrasound scanner using fractal analysis and statistical texture analysis methods. The most useful features were those derived from co-occurrence matrices of the images. Using two features together (contrast of a co-occurrence matrix taken in an oblique direction, and correlation of a co-occurrence matrix taken in the horizontal direction), it was possible to exclude 78% of fibroadenomata, 73% of cysts, and 91% of fibrocystic nodules while maintaining 100% sensitivity for cancer. These findings suggest that ultrasonic image texture analysis is a simple way to markedly reduce the number of benign lesion biopsies without missing additional cancers.<\/jats:p>","DOI":"10.1177\/016173469301500401","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T02:14:01Z","timestamp":1362190441000},"page":"267-285","source":"Crossref","is-referenced-by-count":107,"title":["Improving the Distinction between Benign and Malignant Breast Lesions: The Value of Sonographic Texture Analysis"],"prefix":"10.1177","volume":"15","author":[{"given":"Brian S.","family":"Garra","sequence":"first","affiliation":[{"name":"Department of Radiology Georgetown University Medical Center 3800 Reservoir Road NW Washington, DC 20007-2197"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian H.","family":"Krasner","sequence":"additional","affiliation":[{"name":"Department of Radiology Georgetown University Medical Center 3800 Reservoir Road NW Washington, DC 20007-2197"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Radiology Georgetown University Medical Center 3800 Reservoir Road NW Washington, DC 20007-2197"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ascher","sequence":"additional","affiliation":[{"name":"Department of Radiology Georgetown University Medical Center 3800 Reservoir Road NW Washington, DC 20007-2197"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong K.","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Radiology Georgetown University Medical Center 3800 Reservoir Road NW Washington, DC 20007-2197"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Zeman","sequence":"additional","affiliation":[{"name":"Department of Radiology Georgetown University Medical Center 3800 Reservoir Road NW Washington, DC 20007-2197"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"reference":[{"key":"bibr1-016173469301500401","first-page":"19","volume":"13","author":"Ueno E.","year":"1986","journal-title":"Jpn J. 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