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However, research on social relationships and mortality mainly refers to European and U.S. populations. This study examines structural and functional features of social relationships to understand social isolation among adults aged 50 and older in Mexico. In addition, we analyze that association with mortality, using panel data from a 12-year follow-up from the Mexican Health and Aging Study (2003\u20132015). Results reveal that structural and functional features of social relationships are intertwined, and social isolation was shaped by two aspects that we label lack of socialization and being alone and feeling lonely. After controlling for a series of sociodemographic and health variables, Cox proportional hazard regression models indicate that both aspects significantly increase mortality among older adults in Mexico.<\/jats:p>","DOI":"10.1177\/01640275221078972","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T05:12:51Z","timestamp":1648185171000},"page":"758-769","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Relationship Between Social Isolation and Mortality Among Adults Aged 50 and Older in a 12-year Follow-Up Analysis in Mexico"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4378-8240","authenticated-orcid":false,"given":"Karla","family":"Moreno-Tamayo","sequence":"first","affiliation":[{"name":"Epidemiological and Health Service Research Unit, Aging Area, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Center for Demographic, Urban and Environmental Studies, El Colegio de M\u00e9xico, Ciudad de Mexico, Delegaci\u00f3n Tlalpan, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Manrique-Espinoza","sequence":"additional","affiliation":[{"name":"Center for Evaluation Research and Surveys, National Institute of Public Health, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Mej\u00eda-Pailles","sequence":"additional","affiliation":[{"name":"Independent Consultant, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"bibr1-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36342007000400005"},{"key":"bibr2-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1257\/aer.100.2.205"},{"key":"bibr3-01640275221078972","first-page":"9","volume-title":"Im\u00e1genes de la familia en el cambio de siglo","author":"Ariza M.","year":"2004"},{"key":"bibr4-01640275221078972","first-page":"9","volume":"1","author":"Arriagada I.","year":"2009","journal-title":"Revista Latinoamericana de Estudios de Familia"},{"key":"bibr5-01640275221078972","doi-asserted-by":"publisher","DOI":"10.2307\/347107"},{"key":"bibr6-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(00)00065-4"},{"key":"bibr7-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112674"},{"key":"bibr8-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113351"},{"key":"bibr9-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1111\/spc3.12087"},{"key":"bibr10-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1177\/1745691615570616"},{"key":"bibr11-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(00)00259-8"},{"key":"bibr12-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1093\/med:psych\/9780195126709.003.0001"},{"key":"bibr13-01640275221078972","volume-title":"Proyecciones de la Poblaci\u00f3n de M\u00e9xico y de las Entidades Federativas, 2016-2050 y Conciliaci\u00f3n Demogr\u00e1fica de M\u00e9xico, 1950 -2015","author":"CONAPO","year":"2018"},{"key":"bibr14-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbp037"},{"key":"bibr15-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2017.07.016"},{"key":"bibr16-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116731"},{"key":"bibr17-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.2011.631612"},{"key":"bibr18-01640275221078972","doi-asserted-by":"publisher","DOI":"10.1007\/s10823-015-9278-5"},{"key":"bibr19-01640275221078972","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2021.604449"},{"key":"bibr20-01640275221078972","doi-asserted-by":"publisher","DOI":"10.14718\/ACP.2020.23.1.6"},{"key":"bibr21-01640275221078972","first-page":"35","volume":"77","author":"Guzm\u00e1n J. 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