{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:54:48Z","timestamp":1777913688930,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>Morphogenesis of craniopharyngeal derivatives of the neurohypophysis found in 14 Fischer 344 (F344) rats was studied. The incidence of the craniopharyngeal derivatives was 0.17% in male (7 out of 4,200) and 0.16% in female (7 out of 4,450) F344 rats. Neither a sex-related difference in their incidence nor a strain-related difference in their morphological features was observed. Craniopharyngeal derivatives were composed of aberrant epithelial structures consisting of serous acinar and tubular and fusiform cell structures, and most of these derivatives were associated with Rathke's cleft cysts, which are suggestive of a congenital background. The acinar structures were positive for periodic acid-Schiff reaction and negative for Alcian blue stain. Immunohistochemically, cells forming these structures were positive for cytokeratin, and basal cells of the acinar or tubular structures and some of the fusiform cells showed positive staining for alpha-smooth muscle actin. Electron microscopically, these spindle-shaped basal cells had intracytoplasmic myofilaments with focal density in their cytoplasm, and they were regarded to be myoepithelial cells. These findings strongly indicate that the craniopharyngeal derivatives are not a neoplastic lesion but rather are a developmental aberration derived from the stomatodeum, which is known to be the origin of both nasal and oral epithelial tissues, including the parotid glands, other than Rathke's pouch.<\/jats:p>","DOI":"10.1177\/019262330002800410","type":"journal-article","created":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T19:38:42Z","timestamp":1202499522000},"page":"568-574","source":"Crossref","is-referenced-by-count":8,"title":["Morphogenesis of Craniopharyngeal Derivatives in the Neurohypophysis of Fisher 344 Rats: Abnormally Developed Epithelial Tissues Including Parotid Glands Derived from the Stomatodeum"],"prefix":"10.1177","volume":"28","author":[{"given":"Hijiri","family":"Iwata","sequence":"first","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Hosoi","sequence":"additional","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Mikami","sequence":"additional","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiki","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Fukude-cho, Iwata-gun, Shizuoka 437-1213, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Imazawa","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunitoshi","family":"Mitsumori","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"atypb1","unstructured":"Capen CC, DeLellis RA, Yarrington JT (1991). Pituitary gland, response to injury. In: Handbook of Toxicologic Pathology, Haschek WM, Rousseaux CG (eds). Academic Press, Tokyo, Japan, pp 702-705."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60996-1_8"},{"key":"atypb3","first-page":"161","volume":"2","author":"Giorno R.","year":"1984","journal-title":"Diagn Immunol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300427"},{"key":"atypb5","volume-title":"Rathke-cleft cyst","author":"Ishida Y.","year":"1988"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60996-1_16"},{"key":"atypb7","unstructured":"Katayama S., Ishii J. (1993). Pharyngeal pituitary, persistant remnant of Rathke's pouch, pituitary aplasia, anencephaly. Nihon-Rinshou (separate volume): 99-101 (in Japanese)."},{"key":"atypb8","unstructured":"Kovacs K., Horvath E. (1986). Craniopharyngioma. In: Tumors of the Pituitary Gland, 2nd ed, Armed Forces Institute of Pathology, Washington, DC , pp 237-251."},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(71)90066-1"},{"key":"atypb10","unstructured":"Mackenzie WF, Boorman GA (1990). Pituitary gland. In: Pathology of the Fischer Rat, Boorman GA, Eustis SL, Elwell MR, Mongomery CA, MacKenzie WF (eds). Academic Press, Tokyo , Japan, pp 485-500."},{"key":"atypb11","unstructured":"Mohr U, ed (1994). Craniopharyngioma, benign and craniopharyngioma, malignant. In: International Classification of Rodent Tumors. 6. Endocrine System, International Agency for Research on Cancer (WHO), IARC Scientific Publication 122, Lyon, France, pp 8-10."},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400207"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-2993(11)80299-X"},{"key":"atypb14","unstructured":"Warner NE (1985). Pituitary gland. In: Anderson's Pathology, 8th ed, Kissane JM (ed). C. V. Mosby Company, St. Louis, Missouri, pp 1372-1398."}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262330002800410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262330002800410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:29:17Z","timestamp":1777652957000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262330002800410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1177\/019262330002800410"],"URL":"https:\/\/doi.org\/10.1177\/019262330002800410","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}