{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:55:38Z","timestamp":1777913738747,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>In a carcinogenicity study, a neuronal tumor in the cranial cavity was observed in a 110-week-old female B6C3F1 mouse. At necropsy, the tumor was seen at the site of the pituitary gland. Histologically, the tumor consisted of well-differentiated ganglion cells, nerve fiber\/neuropil-like elements and ganglion-like cells. The tumor was composed mainly of ganglion-like cells, which were arranged in solid sheets interspersed with thin fibrovascular stroma. Nissl substance was detected at the margin in the cytoplasm of well-differentiated ganglion cells, and nerve fibers were identified by the Kluever-Barrera method. Immunohistochemically, the well-differentiated ganglion cells were positive for S-100, neurofilament protein (NF), neuron-specific enolase (NSE), synaptophysin, and chromogranin A. The nerve fiber\/neuropil-like elements were positive for S-100, NF, NSE, and glial fibrillary acidic protein (GFAP), and the ganglion-like cells were strongly positive only for NSE and synaptophysin. On the other hand, there were no pituitary cells, such as prolactin-positive or adrenocorticotropic hormone (ACTH)-positive cells in the tumor tissue. Detailed histopathological examination suggested that the tumor might be a ganglioneuroma arising from the trigeminal ganglion. This report provides additional histopathological evidence of peripheral nerve neoplasms in mice.<\/jats:p>","DOI":"10.1177\/0192623309333786","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T17:49:56Z","timestamp":1240249796000},"page":"343-347","source":"Crossref","is-referenced-by-count":6,"title":["Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 Mouse"],"prefix":"10.1177","volume":"37","author":[{"given":"Yuzo","family":"Yasui","sequence":"first","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasufumi","family":"Ohta","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Ueda","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Kihara","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Hosoi","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shiga","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Imai","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Pathology Laboratory, Biosafety Research Center, Foods Drugs and Pesticides, Iwata, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,4,20]]},"reference":[{"key":"b1-0370343","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478902"},{"key":"b2-0370343","first-page":"151","volume-title":"Atlas of Tumor Pathology, Tumors of the Pituitary Gland","author":"Asa SL","year":"1997","edition":"3"},{"key":"b3-0370343","first-page":"585","volume":"59","author":"Beezley DN","year":"1969","journal-title":"Cornell Vet"},{"key":"b4-0370343","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07973-7_8"},{"key":"b5-0370343","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/52.1.265"},{"key":"b6-0370343","first-page":"381","volume":"113","author":"Hachitanda Y","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"b7-0370343","first-page":"501","volume-title":"Pathology of the Fischer Rat, Reference and Atlas","author":"Hamlin MH","year":"1990"},{"key":"b8-0370343","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60996-1_11"},{"key":"b9-0370343","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch14"},{"key":"b10-0370343","first-page":"485","volume-title":"Pathology of the Fischer Rat, Reference and Atlas","author":"MacKenzie WF","year":"1990"},{"key":"b11-0370343","first-page":"491","volume-title":"Pathology of the Mouse, Reference and Atlas","author":"Mahler JF","year":"1999"},{"key":"b12-0370343","first-page":"509","volume-title":"Pathology of the Mouse, Reference and Atlas","author":"Nyska A","year":"1999"},{"key":"b13-0370343","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.59.833"},{"key":"b14-0370343","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000272"},{"key":"b15-0370343","doi-asserted-by":"publisher","DOI":"10.1080\/01926230290105668"},{"key":"b16-0370343","doi-asserted-by":"publisher","DOI":"10.1354\/vp.44-2-207"},{"key":"b17-0370343","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211342"},{"key":"b18-0370343","doi-asserted-by":"publisher","DOI":"10.1007\/BF00696794"},{"key":"b19-0370343","first-page":"219","volume-title":"Atlas of Tumor Pathology, Tumors of the Peripheral Nervous System","author":"Scheithauer BW","year":"1997","edition":"3"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623309333786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0192623309333786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623309333786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:30:48Z","timestamp":1777653048000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0192623309333786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1177\/0192623309333786"],"URL":"https:\/\/doi.org\/10.1177\/0192623309333786","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}