{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:55:48Z","timestamp":1777913748149,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,8,25]],"date-time":"2009-08-25T00:00:00Z","timestamp":1251158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>A previously undescribed spontaneous cardiomyopathy was identified by routine light microscopic examination of the heart from four clinically healthy purpose-bred cynomolgus monkeys that ranged from four to nine years of age and included 2 males and 2 females. Special stains of Sirius red, Masson\u2019s trichrome, and Mallory\u2019s phosphotungstic acid hematoxylin (PTAH); and immunohistochemistry using anti-CD68, troponin-I, and desmin antibodies were used to facilitate lesion characterization and assess cardiomyocyte viability. Microscopically, the apical to mid-ventricular myocardium to subendocardium had foci of cardiomyocyte disarray with cytoplasmic pallor to stippling and karyomegaly, vacuolization of the perimyseal connective tissue, a meshwork of fibrous tissue that concentrated around medium-sized blood vessels and dissected between or less often replaced affected cardiomyocytes; and a minimal, predominantly macrophage infiltrate. The disrupted cardiomyocytes were immunoreactive to desmin and troponin-I antibodies and had a normal cross-striation pattern by PTAH, indicating the chronic cardiomyopathy was not associated with active cardiomyocyte damage. The consistent distribution and morphology of the cardiomyopathy suggested a common etiology and pathogenesis. The features were reminiscent of chronic catecholamine-induced experimental cardiomyopathy and stress cardiomyopathy in monkeys and humans, respectively. This report documents another spontaneous heart lesion in clinically healthy monkeys for consideration during interpretation of toxicology studies.<\/jats:p>","DOI":"10.1177\/0192623309345692","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T00:18:57Z","timestamp":1251245937000},"page":"814-818","source":"Crossref","is-referenced-by-count":20,"title":["Spontaneous Cardiomyopathy in Cynomolgus Monkeys (\n                    <i>Macaca Fascicularis<\/i>\n                    )"],"prefix":"10.1177","volume":"37","author":[{"given":"Tanja S.","family":"Zabka","sequence":"first","affiliation":[{"name":"Roche Pharmaceuticals, Pathology Department, Non-clinical safety, Palo Alto, CA 94304 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Irwin","sequence":"additional","affiliation":[{"name":"Roche Pharmaceuticals, Pathology Department, Non-clinical safety, Palo Alto, CA 94304 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