{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:56:03Z","timestamp":1777913763605,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>Spontaneous salivary gland tumors in rats are rare. The authors report a poorly differentiated carcinoma of a submandibular gland in a ten-week-old rat that was positive for vimentin. Microscopically, the neoplastic cells showed a diffuse growth pattern in most areas of the tumor mass and a nestlike structure in a part of the peripheral area. Immunohistochemically, the cells were positive for keratin and vimentin but not for \u03b1-smooth muscle actin. Ultrastructurally, desmosome-like structures were observed. Based on these findings, the tumor was diagnosed as a poorly differentiated carcinoma. The origin of the neoplastic cells would be either acinar or ductal cells. This suggests that acinar or ductal cells have the potential to transform into vimentin-expressing cells.<\/jats:p>","DOI":"10.1177\/0192623309358905","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T23:14:32Z","timestamp":1265152472000},"page":"315-318","source":"Crossref","is-referenced-by-count":7,"title":["Spontaneous Poorly Differentiated Carcinoma with Cells Positive for Vimentin in a Salivary Gland of a Young Rat"],"prefix":"10.1177","volume":"38","author":[{"given":"Satomi","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation\u2013Safety Research Laboratory, Kisarazu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Sano","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation\u2013Safety Research Laboratory, Kisarazu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Takagi","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation\u2013Safety Research Laboratory, Kisarazu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyoko","family":"Okada","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation\u2013Safety Research Laboratory, Kisarazu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation\u2013Safety Research Laboratory, Kisarazu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Takagi","sequence":"additional","affiliation":[{"name":"Mitsubishi Tanabe Pharma Corporation\u2013Safety Research Laboratory, Kisarazu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,2,2]]},"reference":[{"key":"bibr1-0192623309358905","first-page":"89","volume-title":"Pathology of Tumours in Laboratory Animals","volume":"1","author":"Elwell M. 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