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The histopathologic lesions associated with organ dysfunction are largely unknown because of the low rate of mortality of ATLS in humans and the few cases of ATLS identified in laboratory animals. Here, we describe histologic, immunohistochemical, and electron microscopic analyses of thirty-one ATLS cases from a cohort of 499 mice that are prone to spontaneous lymphoblastic lymphoma owing to genetic defects in DNA replication fidelity. Seventy-three percent of our cohort died with lymphoblastic lymphoma, and 8% of affected mice died with diffuse microthromboemboli consistent with ATLS. Mice with ATLS had a high spontaneous mortality rate (&gt;50%), a large tumor burden with disseminated disease, and evidence of leukemia. Blood vessels in the lung, kidney, and other organs were occluded by microthromboemboli composed of chromatin, cellular debris, fibrin, platelets, and entrapped erythrocytes and malignant cells. This case series suggests that ATLS can occur at high frequency in mice with disseminated lymphoblastic lymphoma and leads to a high rate of spontaneous death from microthromboemboli.<\/jats:p>","DOI":"10.1177\/0192623310362249","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T22:08:04Z","timestamp":1267222084000},"page":"476-485","source":"Crossref","is-referenced-by-count":17,"title":["Case Series"],"prefix":"10.1177","volume":"38","author":[{"given":"Piper M.","family":"Treuting","sequence":"first","affiliation":[{"name":"Department of Comparative Medicine, University of Washington, Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M.","family":"Albertson","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, University of Washington, Seattle WA"},{"name":"Department of Pathology, University of Washington, Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley D.","family":"Preston","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington, Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907147106"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11612"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02089.x"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.0177"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.09.045"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.066006404.x"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197804000-00012"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30021"},{"key":"e_1_3_3_10_1","first-page":"1301","article-title":"Tumorigenesis in Mlh1 and Mlh1\/Apc1638N mutant mice","volume":"59","author":"Edelmann W.","year":"1999","unstructured":"Edelmann W., Yang K., Kuraguchi M., Heyer J., Lia M., Kneitz B., Fan K., Brown A. 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