{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:37:20Z","timestamp":1787765840388,"version":"build-2784847793"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>The occurrence and severity of spontaneous chronic progressive nephropathy (CPN) in control male F344 rats as well as the frequency of treatment-related CPN exacerbation were histopathologically reevaluated. A series of 43 National Toxicology Program (NTP) 90-day toxicity studies comparing the influence of NIH-07 or NTP-2000 diets was examined. Relationships between the histopathologic findings at 90 days and renal tubule proliferative lesions recorded in subsequent 2-year bioassays for 24 chemicals were statistically analyzed. CPN lesions were observed in 100% of the control male rats regardless of diet, but CPN was more severe in control rats fed NIH-07. Approximately one-third of the 90-day studies demonstrated a treatment-related exacerbation of CPN severity, which was independent of diet. For chemicals that proceeded to 2-year bioassays, all studies with a statistically significant increase in renal tubule tumors (RTT) at 2 years had treatment-related exacerbation of CPN in the 90-day and 2-year studies. These findings indicate that CPN occurs ubiquitously in young male F344 rats and that treatment-related exacerbation of CPN in 90-day studies is a relatively common occurrence, having the potential to be predictive of an increased incidence of RTT in subsequent 2-year bioassays.<\/jats:p>","DOI":"10.1177\/0192623310388432","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T13:41:58Z","timestamp":1300714918000},"page":"381-389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Chronic Progressive Nephropathy in Male F344 Rats in 90-Day Toxicity Studies"],"prefix":"10.1177","volume":"39","author":[{"given":"Greg S.","family":"Travlos","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon C.","family":"Hard","sequence":"additional","affiliation":[{"name":"Private consultant, Tairua, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Betz","sequence":"additional","affiliation":[{"name":"SRA International, Inc., Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace E.","family":"Kissling","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"bibr1-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1080\/03610738208258390"},{"key":"bibr2-0192623310388432","doi-asserted-by":"publisher","DOI":"10.2307\/2531856"},{"key":"bibr3-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117531"},{"key":"bibr4-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309343779"},{"key":"bibr5-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9086313"},{"key":"bibr6-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/32.3.258"},{"key":"bibr7-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(91)90060-2"},{"key":"bibr8-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1177\/019262339502300310"},{"key":"bibr9-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701338941"},{"key":"bibr10-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1177\/019262339402200501"},{"key":"bibr11-0192623310388432","doi-asserted-by":"publisher","DOI":"10.3109\/10408447709003377"},{"key":"bibr12-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-3367-5_7"},{"key":"bibr13-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1177\/019262339802600112"},{"key":"bibr14-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/69.1.30"},{"key":"bibr15-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1080\/10408440802368642"},{"key":"bibr16-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1080\/01926230490422574"},{"key":"bibr17-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9399313"},{"key":"bibr18-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.10.018"},{"key":"bibr19-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1177\/019262339702500202"},{"key":"bibr20-0192623310388432","volume-title":"Nonparametric Statistical Methods","author":"Hollander M.","year":"1973"},{"key":"bibr21-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1177\/019262330002800604"},{"key":"bibr22-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-364930-0.50011-7"},{"key":"bibr23-0192623310388432","doi-asserted-by":"publisher","DOI":"10.1080\/10408440490265210"},{"key":"bibr24-0192623310388432","volume-title":"Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quatification","author":"Lock E. 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