{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:59:53Z","timestamp":1791255593047,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T00:00:00Z","timestamp":1337299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>\n                    Alloxan-induced diabetic rats showed proliferative changes in the forestomach, accompanied by chronic inflammation, and one lesion progress to squamous cell carcinoma (SCC) without distant metastasis. The authors demonstrated that these lesions might be caused by\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    infection. Antimicrobial therapy, particularly tetracycline treatment, has been blamed for a reduction in the number of competing bacterial organisms, which is frequently mentioned as a cause of candidiasis. The objective of this study is to ascertain whether or not tetracycline treatment can accelerate early-onset of\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    infection and the proliferative changes in this diabetic model. Alloxan-induced diabetic rats were given chlorinated water (AL group) and tetracycline solution (0.1% during week 1 and 0.01% thereafter) as drinking water (AT group). They were sacrificed after 25 weeks of drinking the treated water. The infection rate with\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    in the AT group was significantly higher than in the AL group. The incidence and severity of the squamous cell hyperplasia were enhanced in the AT group compared to the AL group. The proliferative lesions were consistently accompanied by inflammation and\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    infection in both groups. SCC was detected in one case in the AT group. These findings demonstrate that tetracycline induces\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    infection and enhances forestomach proliferative lesions in alloxan-induced diabetic rats.\n                  <\/jats:p>","DOI":"10.1177\/0192623312447287","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T11:24:01Z","timestamp":1337513041000},"page":"1014-1019","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Antimicrobial Agent, Tetracycline, Enhanced Upper Alimentary Tract\n                    <i>Candida albicans<\/i>\n                    Infection and Its Related Mucosal Proliferation in Alloxan-induced Diabetic Rats"],"prefix":"10.1177","volume":"40","author":[{"given":"Tomoya","family":"Sano","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyokazu","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kodama","sequence":"additional","affiliation":[{"name":"Laboratory of Clinicopathological Therapeutics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Narama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,5,18]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.47.2.480-483.1985"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1998.tb00251.x"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.10.5.607"},{"key":"e_1_3_3_5_1","first-page":"263","article-title":"Incidence of multiple primary cancers. 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