{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:07:45Z","timestamp":1791043665258,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>The detection of drug-induced hepatotoxicity remains an important safety issue in drug development. A liver-specific microRNA species, microRNA-122 (miR-122), has recently shown potential for predicting liver injury in addition to the standard hepatic injury biomarkers. The objective of this study was to measure miR-122 together with several other liver markers in distinct settings of acute liver toxicity in rats to determine the value of miR-122 as a biomarker for liver injury in this species. Rats were exposed to 3 well-established liver toxicants (acetaminophen, allyl alcohol, and \u03b1-naphthyl isothiocyanate), a liver-enzyme inducer (phenobarbital), or a cardiotoxicant (doxorubicin). There was a clear increase in plasma miR-122 following administration of acetaminophen, allyl alcohol, and \u03b1-naphthyl isothiocyanate. The response of miR-122 paralleled that of other markers and was consistent with liver injury as indicated by histopathological evaluation. Furthermore, the changes in miR-122 were detected earlier than standard liver injury markers and exhibited a wide dynamic range. In contrast, miR-122 responses to phenobarbital and doxorubicin were low. Based on these findings, miR-122 shows significant promise and may provide added value for assessing liver toxicity in drug development.<\/jats:p>","DOI":"10.1177\/0192623312464436","type":"journal-article","created":{"date-parts":[[2012,11,10]],"date-time":"2012-11-10T21:05:34Z","timestamp":1352581534000},"page":"795-804","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":66,"title":["Evaluation of miR-122 and Other Biomarkers in Distinct Acute Liver Injury in Rats"],"prefix":"10.1177","volume":"41","author":[{"given":"Sofie","family":"Starckx","sequence":"first","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameesha","family":"Batheja","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research and Development, L.L.C., Raritan, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert R.","family":"Verheyen","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra De","family":"Jonghe","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Steemans","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram Van","family":"Dijck","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Singer","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research and Development, L.L.C., Raritan, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Bogdan","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research and Development, L.L.C., Raritan, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Snoeys","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Vinken","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research and Development, L.L.C., Raritan, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky Van","family":"Gompel","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Guzzie-Peck","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research and Development, L.L.C., Raritan, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Lampo","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Lammens","sequence":"additional","affiliation":[{"name":"Drug Safety Sciences, Janssen Research & Development, A Division of Janssen Pharmaceutica N.V., Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"bibr1-0192623312464436","first-page":"669","volume":"218","author":"AVMA","year":"2007","journal-title":"JAVMA"},{"key":"bibr2-0192623312464436","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.4.341"},{"key":"bibr3-0192623312464436","doi-asserted-by":"publisher","DOI":"10.1517\/17425250902927386"},{"key":"bibr4-0192623312464436","first-page":"295","volume":"7","author":"Atzori L.","year":"1989","journal-title":"Drug Metabol Drug Interact"},{"key":"bibr5-0192623312464436","unstructured":"Belgian Law (October 18, 1991): Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes. 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