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Supportive treatments for regeneration of the remaining liver may be useful for the recovery of these patients. We demonstrated that nutritional hepatotrophic factors (NHF) is an effective regenerative stimulus for cirrhotic livers in rats subjected to partial hepatectomy (PH). The rats with thioacetamide-induced cirrhosis were subjected to PH, and they were divided into 2 groups. One group received intraperitoneal administration of NHF, and the other group received saline solution. After 12 days, biometric data, collagen content, hepatocyte regeneration (proliferation cell nuclear antigen immunochemistry), and profibrotic gene expression (Collagen-\u03b11, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase 1, and transforming growth factor beta 1) were assessed. The results indicated that the rats treated with NHF after PH had an increased liver size, a reduced amount of collagen, and a higher hepatocyte proliferation index compared with the rats that underwent PH alone. In addition, collagen-\u03b11 gene expression was decreased in the NHF-treated rats. Thus, postoperative improvement in the liver morphology following NHF treatment may cause a significant decrease in the risk of liver failure and mortality after hepatic resection.<\/jats:p>","DOI":"10.1177\/0192623313486316","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:02:21Z","timestamp":1366848141000},"page":"414-421","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Parenteral Solution of Nutritional Hepatotrophic Factors Improves Regeneration in Thioacetamide-induced Cirrhotic Livers after Partial Hepatectomy"],"prefix":"10.1177","volume":"42","author":[{"given":"Mauricio de Rosa","family":"Trotta","sequence":"first","affiliation":[{"name":"Departamento de Patologia e Medicina Legal, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandara Murad","family":"Cajaiba","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Os\u00f3rio Miguel","family":"Parra","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L\u00facia Zaidan","family":"Dagli","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Hernandez-Blazquez","sequence":"additional","affiliation":[{"name":"Departamento de Cirurgia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"bibr1-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1002\/jtra.1049"},{"key":"bibr2-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.04.002"},{"key":"bibr3-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5825"},{"key":"bibr4-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.2.G245"},{"key":"bibr5-0192623313486316","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.09.83"},{"key":"bibr6-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00433.x"},{"key":"bibr7-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.21408"},{"key":"bibr8-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"bibr9-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032010000100014"},{"key":"bibr10-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2008001100008"},{"key":"bibr11-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412083312303"},{"key":"bibr12-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004001100015"},{"key":"bibr13-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009005000027"},{"key":"bibr14-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70096-6"},{"key":"bibr15-0192623313486316","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.02.003"},{"key":"bibr16-0192623313486316","first-page":"186","volume":"12","author":"Higgins G. 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