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Compound-induced pancreatitis is not a common event in toxicology or drug development, but it becomes a significant liability when encountered. Understanding the species-specific differences in physiology is essential to understand the underlying pathobiology of pancreatic disease in animal models and its relevance to human disease. This review will mainly focus on understanding the morphology and physiology of the pancreas, unique islet\u2013exocrine interactions, and pancreatitis.<\/jats:p>","DOI":"10.1177\/0192623313509907","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T20:13:51Z","timestamp":1383596031000},"page":"207-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":68,"title":["Overview of Exocrine Pancreatic Pathobiology"],"prefix":"10.1177","volume":"42","author":[{"given":"Arun R.","family":"Pandiri","sequence":"first","affiliation":[{"name":"Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,3]]},"reference":[{"key":"bibr1-0192623313509907","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199401000-00018"},{"key":"bibr2-0192623313509907","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94174-V"},{"key":"bibr3-0192623313509907","first-page":"79","volume":"42","author":"Aughsteen A. 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