{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:58:35Z","timestamp":1777913915923,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T00:00:00Z","timestamp":1401062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic indications. While generally considered safe, the number of reported complications with tissue fillers is growing. Nevertheless, there is no specific animal model that is considered as the gold standard for assessing safety or efficacy of tissue fillers, and there are very little data on interspecies differences in reaction to these products. Here, we report on interspecies differences in reaction to a subcutaneous injectable co-polyester, composed of castor oil and citric acid. Comparison of the histopathological local tissue changes following 1-month postimplantation, indicated that in rats the reaction consisted of cavities, surrounded by relatively thin fibrotic enveloping capsule. In contrast, an unexpected severe inflammatory granulomatous reaction was noticed in Sinclair minipigs. To our knowledge, this is the first report on significant interspecies differences in sensitivity to tissue fillers. It emphasizes the importance of using the appropriate animal model for performing preclinical biocompatibility assays for biodegradable polymers, tissue fillers, and implanted medical devices in general. It also makes the Sinclair minipig subject for scrutiny as an animal model in future biocompatibility studies.<\/jats:p>","DOI":"10.1177\/0192623314534995","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T22:50:25Z","timestamp":1401144625000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Interspecies Differences in Reaction to a Biodegradable Subcutaneous Tissue Filler"],"prefix":"10.1177","volume":"43","author":[{"given":"Yuval","family":"Ramot","sequence":"first","affiliation":[{"name":"Hadassah\u2013Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Touitou","sequence":"additional","affiliation":[{"name":"Juvenis Ltd., M. P Misgav, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galit","family":"Levin","sequence":"additional","affiliation":[{"name":"Juvenis Ltd., M. P Misgav, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana E.","family":"Ickowicz","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran Haim","family":"Zada","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa","family":"Abbas","sequence":"additional","affiliation":[{"name":"Juvenis Ltd., M. P Misgav, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Yankelson","sequence":"additional","affiliation":[{"name":"Juvenis Ltd., M. P Misgav, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham J.","family":"Domb","sequence":"additional","affiliation":[{"name":"Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Nyska","sequence":"additional","affiliation":[{"name":"Tel Aviv University and consultant in toxicologic pathology, Timrat, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,26]]},"reference":[{"key":"bibr1-0192623314534995","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1468-3083.2007.02354.x","volume":"22","author":"Alijotas-Reig J.","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"bibr2-0192623314534995","volume-title":"Regional Differences in Adipose Tissue of the Sinclair Minipig","author":"Booker S. 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