{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:11:30Z","timestamp":1793214690231,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>This review focuses on the anatomy, histologic preparation, and pathologic evaluation of extraparenchymal bile and pancreatic ducts (BPDs) and their openings at the duodenal papillae in the cynomolgus macaque ( Macaca fascicularis), the Beagle dog ( Canis familiaris), the Wistar Hanover rat ( Rattus norvegicus), and the CD1 mouse ( Mus musculus). In nonclinical safety assessment, intraparenchymal BPDs (with sections of liver and pancreas, respectively) are evaluated routinely. However, detailed evaluation of the extraparenchymal BPDs or the duodenal papillae is not included. In the context of nonclinical safety assessment studies, this review describes situations in which evaluation of extraparenchymal ductal structures and duodenal papillae may be useful in characterizing test article\u2013related changes; elucidates anatomic similarities between human, macaque, and dog and notable differences in rats and mice; and consolidates the information required for the histopathologic evaluation of these tissues.<\/jats:p>","DOI":"10.1177\/0192623314560612","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T22:15:20Z","timestamp":1422569720000},"page":"651-661","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Extraparenchymal Bile\/Pancreatic Ducts and Duodenal Papillae"],"prefix":"10.1177","volume":"43","author":[{"given":"Kapil","family":"Vashisht","sequence":"first","affiliation":[{"name":"Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry L.","family":"Nady","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita D.","family":"Engler","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Kelsch","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan N.","family":"Lynk","sequence":"additional","affiliation":[{"name":"Covance Laboratories, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Cape","sequence":"additional","affiliation":[{"name":"Covance Laboratories, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenther","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Covance Laboratories, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Meseck","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"bibr1-0192623314560612","first-page":"1302","volume":"48","author":"Aldrighetti L.","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"bibr2-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012982"},{"key":"bibr3-0192623314560612","first-page":"1","volume":"119","author":"Anand C.","year":"1975","journal-title":"J Anat"},{"key":"bibr4-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1007\/BF02136225"},{"key":"bibr5-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1080\/01926230390183751"},{"key":"bibr6-0192623314560612","unstructured":"Center for Drug Evaluation and Research approval package for amlexanox oral paste. (1996). Accessed September 23, 2014. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/96\/020511ap.pdf."},{"key":"bibr7-0192623314560612","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-3565(25)07780-8","volume":"104","author":"Chen J. Y.","year":"1952","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr8-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2008.05.004"},{"key":"bibr9-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(83)90335-6"},{"key":"bibr10-0192623314560612","first-page":"363","volume":"23","author":"Farinon A. M.","year":"1975","journal-title":"Chir Patol Sper"},{"key":"bibr11-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0332-8"},{"key":"bibr12-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53856-7.00009-9"},{"key":"bibr13-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1958.38.4.675"},{"key":"bibr14-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218461"},{"key":"bibr15-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1007\/112_2013_14"},{"key":"bibr16-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080414"},{"key":"bibr17-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2004.10.004"},{"key":"bibr18-0192623314560612","first-page":"317","volume":"24","author":"Karski J.","year":"1965","journal-title":"Macacus rhesus and Macacus cynomolgus [in Polish]. Folia Morphologica (Warsz)"},{"key":"bibr19-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.035"},{"key":"bibr20-0192623314560612","first-page":"361","volume":"25","author":"Levine W. G.","year":"1981","journal-title":"Prog Drug Res"},{"key":"bibr21-0192623314560612","first-page":"208","volume":"14","author":"Lillemoe K. D.","year":"2003","journal-title":"Semin Gastrointest Dis"},{"key":"bibr22-0192623314560612","first-page":"13","volume":"4","author":"Nyland T. G.","year":"1989","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"bibr23-0192623314560612","first-page":"779","volume":"124","author":"Obuoforibo A. A.","year":"1977","journal-title":"J Anat"},{"key":"bibr24-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<571::AID-JEMT3>3.0.CO;2-I"},{"key":"bibr25-0192623314560612","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241100-00005"},{"key":"bibr26-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.1.1549695"},{"key":"bibr27-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(00)00203-4"},{"key":"bibr28-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000123"},{"key":"bibr29-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.5.567"},{"key":"bibr30-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20664"},{"key":"bibr31-0192623314560612","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/cphy.c120019","volume":"3","author":"Tabibian J. H.","year":"2013","journal-title":"Compr Physiol"},{"key":"bibr32-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06072.x"},{"key":"bibr33-0192623314560612","first-page":"167","volume-title":"Comparative Anatomy and Histology: A Mouse and Human Atlas","author":"Treuting P. M.","year":"2011","edition":"1"},{"key":"bibr34-0192623314560612","first-page":"193","volume":"7","author":"Tsuji K.","year":"2006","journal-title":"JOP"},{"key":"bibr35-0192623314560612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00658.x"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623314560612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0192623314560612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623314560612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:36:49Z","timestamp":1777653409000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0192623314560612"}},"subtitle":["Pathologic Evaluation in Nonclinical Species\u2014A Brief Review"],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1177\/0192623314560612"],"URL":"https:\/\/doi.org\/10.1177\/0192623314560612","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}