{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:59:44Z","timestamp":1777913984351,"version":"3.51.4"},"reference-count":90,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>The 2016 annual National Toxicology Program Satellite Symposium, entitled \u201cPathology Potpourri\u201d was held in San Diego, CA, at the Society of Toxicologic Pathology\u2019s (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and\/or nomenclature issues. This article presents summaries of the speakers\u2019 talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal\/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma\/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver\/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma, and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria collaborations.<\/jats:p>","DOI":"10.1177\/0192623316672074","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T20:53:55Z","timestamp":1478552035000},"page":"11-51","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Proceedings of the 2016 National Toxicology Program Satellite Symposium"],"prefix":"10.1177","volume":"45","author":[{"given":"Susan A.","family":"Elmore","sequence":"first","affiliation":[{"name":"National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian S.","family":"Chen","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Inc., Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schantel","family":"Hayes-Bouknight","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Inc., Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica S.","family":"Hoane","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Inc., Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyathanahalli","family":"Janardhan","sequence":"additional","affiliation":[{"name":"Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda H.","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Inc., Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nolte","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Szabo","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Inc., Durham, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle A.","family":"Willson","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratories, Inc., Sterling, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Malarkey","sequence":"additional","affiliation":[{"name":"National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"bibr1-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310391680"},{"key":"bibr2-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400603"},{"key":"bibr3-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309354111"},{"key":"bibr4-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1201\/b18160-3"},{"key":"bibr5-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1201\/b18160-20"},{"key":"bibr6-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311427713"},{"key":"bibr7-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1002\/9780813810379"},{"key":"bibr8-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01639.x"},{"key":"bibr9-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310374329"},{"key":"bibr10-0192623316672074","volume-title":"Cell and Tissue Ultrastructure: A Functional Perspective","author":"Cross P. C.","year":"1993"},{"key":"bibr11-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311431466"},{"key":"bibr12-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415759-0.00061-3"},{"key":"bibr13-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1293\/tox.27.1S"},{"key":"bibr14-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V39.6.826.826"},{"key":"bibr15-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312467102"},{"key":"bibr16-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623313508020"},{"key":"bibr17-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314555526"},{"key":"bibr18-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623316631844"},{"key":"bibr19-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3180ca8a49"},{"key":"bibr20-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.0215"},{"key":"bibr21-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.061"},{"key":"bibr22-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057641"},{"key":"bibr23-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1993.tb00446.x"},{"key":"bibr24-0192623316672074","volume-title":"Ultrastructural Pathology of the Cell and Matrix","author":"Ghadially F. N.","year":"1997"},{"key":"bibr25-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90208-9"},{"key":"bibr26-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199403000-00006"},{"key":"bibr27-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044452771-4\/50015-8"},{"key":"bibr28-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53856-7.00012-9"},{"key":"bibr29-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2530"},{"key":"bibr30-0192623316672074","first-page":"501","volume-title":"Pathology of the Fischer Rat: Reference and Atlas","author":"Hamlin M. H.","year":"1990"},{"key":"bibr31-0192623316672074","unstructured":"Hoenerhoff M. J., Hill G. D., Gruebbel M. M. (2015aAdrenal gland, cortex\u2013hypertrophy Nonneoplastic Lesion Atlas NTP. In Adrenal Gland (Rosol T. J., Flake G., reviewers). Accessed August 1, 2016. http:\/\/ntp.niehs.nih.gov\/nnl\/hepatobiliary\/liver\/hnecrossc\/index.htm."},{"key":"bibr32-0192623316672074","unstructured":"Hoenerhoff M. J., Hill G. D., Gruebbel M. M. (2015b Adrenal gland\u2013hyperplasia\u2013Nonneoplastic Lesion Atlas NTP. In Adrenal Gland (Rosol T. J., Flake G., reviewers). Accessed August 1, 2016. http:\/\/ntp.niehs.nih.gov\/nnl\/hepatobiliary\/liver\/hnecrossc\/index.htm."},{"key":"bibr33-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.4.1138"},{"key":"bibr34-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1112"},{"key":"bibr35-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300220"},{"key":"bibr36-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1746"},{"key":"bibr37-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312439125"},{"key":"bibr38-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12309"},{"key":"bibr39-0192623316672074","volume-title":"Pathology and Genetics of Tumours of the Nervous System","author":"Kleihues P.","year":"2000"},{"key":"bibr40-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312452492"},{"key":"bibr41-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90326-0"},{"key":"bibr42-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(89)90103-5"},{"key":"bibr43-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623313502258"},{"key":"bibr44-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-76715-4_12"},{"key":"bibr45-0192623316672074","first-page":"443","volume-title":"Pathology of the Fischer Rat","author":"Leininger J. R.","year":"1990"},{"key":"bibr46-0192623316672074","volume-title":"Manual of Diagnostic Cytology","author":"Leong A. S.-Y.","year":"2003"},{"key":"bibr47-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90311-E"},{"key":"bibr48-0192623316672074","first-page":"498","volume-title":"Diagnostic Pathology Soft Tissue Tumors","author":"Lindberg M. R.","year":"2016"},{"key":"bibr49-0192623316672074","unstructured":"Little P., Rao D. B. (2014). Brain\u2013cholesterol clefts\u2013Nonneoplastic Lesion Atlas NTP (Morrison J. P., Sills R. C., reviewers). Accessed August 1, 2016. http:\/\/ntp.niehs.nih.gov\/nnl\/hepatobiliary\/liver\/hnecrossc\/index.htm."},{"key":"bibr50-0192623316672074","unstructured":"MacKenzie W. F., Alison R. H. (1990). Heart. In Pathology of the Fischer rat. (Boorman Eustis, Elwell Montgomery, MacKenzie eds.), pp. 461\u201371. Academic Press."},{"key":"bibr51-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2013.04.009"},{"key":"bibr52-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309338385"},{"key":"bibr53-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312463987"},{"key":"bibr54-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1293\/tox.26.55"},{"key":"bibr55-0192623316672074","unstructured":"NTP (National Toxicology Program). (2016). Historical Controls. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC. Accessed August 1, 2016. http:\/\/ntp.niehs.nih.gov\/results\/dbsearch\/historical\/index.html."},{"key":"bibr56-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.02.003"},{"key":"bibr57-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181658c14"},{"key":"bibr58-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800208"},{"key":"bibr59-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.10.1052"},{"key":"bibr60-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2014.07.077"},{"key":"bibr61-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0509-x"},{"key":"bibr62-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.9.2.353"},{"key":"bibr63-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2005.tb00059.x"},{"key":"bibr64-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805747105"},{"key":"bibr65-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.07.003"},{"key":"bibr66-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1982.tb00277.x"},{"key":"bibr67-0192623316672074","first-page":"2828","volume":"53","author":"Plante I.","year":"2011","journal-title":"J Vis Exp"},{"key":"bibr68-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415759-0.00058-3"},{"key":"bibr69-0192623316672074","volume-title":"Mouse Development: Patterning, Morphogenesis, and Organogenesis","author":"Rossant J.","year":"2002"},{"key":"bibr70-0192623316672074","unstructured":"Ruben Z., Arceo R.J., Bishop S.P., Elweil M.R., Kerns W.E., Mesfin G.M., Sandusky G.E., Van Vlect J.F. (1997). Proliferative lesions of the heart and vasculature in rats. In Guides for Toxicologic Pathology. STP\/ARP\/AFIP, Washington, DC. Accessed August 1, 2016. https:\/\/www.toxpath.org\/ssdnc\/CardiovascularPro.pdf."},{"key":"bibr71-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309335060"},{"key":"bibr72-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/030098589703400612"},{"key":"bibr73-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1983.144"},{"key":"bibr74-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780428"},{"key":"bibr75-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623316630836"},{"key":"bibr76-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0192623316660769"},{"key":"bibr77-0192623316672074","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.32.412"},{"key":"bibr78-0192623316672074","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.4049\/jimmunol.158.7.3197","volume":"158","author":"Usui T.","year":"1997","journal-title":"J Immunol"},{"key":"bibr79-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1354\/vp.08-VP-0012-V-BC"},{"key":"bibr80-0192623316672074","volume-title":"Veterinary Neuropathology: Essentials of Theory and Practice","author":"Vandevelde M.","year":"2012"},{"key":"bibr81-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1177\/0300985811429811"},{"key":"bibr82-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600941340"},{"key":"bibr83-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490410215"},{"key":"bibr84-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90113-2"},{"key":"bibr85-0192623316672074","unstructured":"Willson G. A., Cimon K. Y. (Cesta M. F., Herbert R. A., Brix A., Malarkey D. E., Sills R. C. eds.) (2015). Uterus - Endometrial Stromal Polyp. In National Toxicology Program Non-neoplastic Lesion Atlas (Cesta H. R. A., Brix A M.F., Malarkey D.E., Sills R.C., reviewers), Vol. 2016. Accessed August 1, 2016. http:\/\/ntp.niehs.nih.gov\/nnl\/hepatobiliary\/liver\/hnecrossc\/index.htm."},{"key":"bibr86-0192623316672074","volume-title":"Withrow & MacEwen\u2019s Small Animal Clinical Oncology","author":"Withrow J. S.","year":"2001"},{"key":"bibr87-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20723"},{"key":"bibr88-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.047605"},{"key":"bibr89-0192623316672074","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-85"},{"key":"bibr90-0192623316672074","doi-asserted-by":"publisher","DOI":"10.3171\/2011.5.JNS11451"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623316672074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0192623316672074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623316672074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:38:13Z","timestamp":1777653493000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0192623316672074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,11]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/0192623316672074"],"URL":"https:\/\/doi.org\/10.1177\/0192623316672074","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,11]]}}}