{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:51:59Z","timestamp":1790805119032,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ESO23513"],"award-info":[{"award-number":["P30 ESO23513"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["U01ES027288"],"award-info":[{"award-number":["U01ES027288"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["U54OH007550"],"award-info":[{"award-number":["U54OH007550"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    Particulate exposure has been implicated in the development of a number of neurological maladies such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer\u2019s disease, and idiopathic Parkinson\u2019s disease. Only a few studies have focused on the olfactory pathway as a portal through which combustion-generated particles may enter the brain. The primary objective of this study was to define the deposition, uptake, and transport of inhaled ultrafine iron\u2013soot particles in the nasal cavities of mice to determine whether combustion-generated nanoparticles reach the olfactory bulb via the olfactory epithelium and nerve fascicles. Adult female C57B6 mice were exposed to iron\u2013soot combustion particles at a concentration of 200 \u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    , which included 40 \u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    of iron oxide nanoparticles. Mice were exposed for 6 hr\/day, 5 days\/week for 5 consecutive weeks (25 total exposure days). Our findings visually demonstrate that inhaled ultrafine iron\u2013soot reached the brain via the olfactory nerves and was associated with indicators of neural inflammation.\n                  <\/jats:p>","DOI":"10.1177\/0192623317729222","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T06:07:29Z","timestamp":1505455649000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":78,"title":["Repeated Iron\u2013Soot Exposure and Nose-to-brain Transport of Inhaled Ultrafine Particles"],"prefix":"10.1177","volume":"46","author":[{"given":"Laurie E.","family":"Hopkins","sequence":"first","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia A.","family":"Laing","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Peake","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Uyeminami","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah M.","family":"Mack","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"},{"name":"Institute of Human Nutrition, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"Smiley-Jewell","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6868-7572","authenticated-orcid":false,"given":"Kent E.","family":"Pinkerton","sequence":"additional","affiliation":[{"name":"Center for Health and the Environment, University of California, Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,15]]},"reference":[{"key":"bibr1-0192623317729222","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.06.001"},{"key":"bibr2-0192623317729222","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.10.006"},{"key":"bibr3-0192623317729222","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22343"},{"key":"bibr4-0192623317729222","doi-asserted-by":"publisher","DOI":"10.2174\/187152710791012053"},{"key":"bibr5-0192623317729222","unstructured":"Connor N. 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