{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:00:59Z","timestamp":1777914059048,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>In a 2-year carcinogenicity study, we identified a spontaneous cholangiofibrosis in a control male Wistar rat. This lesion has long been considered as a compound-related change, with no spontaneous cases reported in the Wistar rat. In addition to routine hematoxylin and eosin stains evaluation, we applied Masson\u2019s trichrome staining, Alcian blue-periodic acid\u2013Schiff staining, and OV-6 immunohistochemistry staining. The special staining demonstrated the fibrous component in the interstitium and intestinal metaplasia of the epithelium (presence of goblet cells), while the positive anti-OV-6 reaction indicated the bile duct origin of the epithelium. These results help to confirm the diagnosis of cholangiofibrosis in this case. We report this rare case to alert pathologists that spontaneous cholangiofibrosis does occur in Wistar rats.<\/jats:p>","DOI":"10.1177\/0192623319842549","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:23:58Z","timestamp":1555374238000},"page":"556-560","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Spontaneous Cholangiofibrosis in a Wistar Rat"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-2123","authenticated-orcid":false,"given":"Tao","family":"Chen","sequence":"first","affiliation":[{"name":"WestChina-Frontier PharmaTech Co., Ltd., Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"WestChina-Frontier PharmaTech Co., Ltd., Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaung","family":"Qiu","sequence":"additional","affiliation":[{"name":"WestChina-Frontier PharmaTech Co., Ltd., Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Mann","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratories, Inc., Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"bibr1-0192623319842549","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80051-7"},{"key":"bibr2-0192623319842549","first-page":"199","volume-title":"Pathology of Tumours in Laboratory Animals. 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