{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:06Z","timestamp":1790808186109,"version":"4.1.0"},"reference-count":85,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100002193","name":"The Dr. Robert and Carol Deibel Family Endowment","doi-asserted-by":"publisher","award":["362470"],"award-info":[{"award-number":["362470"]}],"id":[{"id":"10.13039\/100002193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    Two environmental factors, crystalline silica (cSiO\n                    <jats:sub>2<\/jats:sub>\n                    ), a toxic airborne particle encountered occupationally, and docosahexaenoic acid (DHA), a dietary omega-3 highly unsaturated fatty acid (HUFA), have the potential to influence the development of systemic lupus erythematosus (lupus). Using the NZBWF1 mouse, which spontaneously develops lupus, we found that intranasal exposure to cSiO\n                    <jats:sub>2<\/jats:sub>\n                    significantly decreases latency and promotes rapid progression of the disease. Specifically, cSiO\n                    <jats:sub>2<\/jats:sub>\n                    induces the development of ectopic lymphoid structures (ELS) containing germinal centers in the lungs that yield vigorous and diverse autoantibody responses locally and systemically. Transcriptomic analysis revealed that cSiO\n                    <jats:sub>2<\/jats:sub>\n                    promotes a robust type I interferon gene signature that likely precipitates ELS neogenesis. Intriguingly, dietary supplementation with human-relevant doses of DHA impedes cSiO\n                    <jats:sub>2<\/jats:sub>\n                    -induced gene expression, ELS neogenesis, autoantibody elevation, and glomerulonephritis in this lupus-prone mouse model. Together, our findings point to the feasibility of enhancing tissue omega-3 HUFAs as a personalized nutritional intervention to impede onset and progression of environment-triggered autoimmune disease.\n                  <\/jats:p>","DOI":"10.1177\/0192623319878398","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T12:27:07Z","timestamp":1573734427000},"page":"1004-1011","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Lupus, Silica, and Dietary Omega-3 Fatty Acid Interventions"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-4616","authenticated-orcid":false,"given":"Kathryn A.","family":"Wierenga","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA"},{"name":"Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-0824","authenticated-orcid":false,"given":"Jack R.","family":"Harkema","sequence":"additional","affiliation":[{"name":"Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA"},{"name":"Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Pestka","sequence":"additional","affiliation":[{"name":"Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA"},{"name":"Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA"},{"name":"Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"bibr1-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30546-X"},{"key":"bibr2-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30237-5"},{"key":"bibr3-0192623319878398","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150814269"},{"key":"bibr4-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23925"},{"key":"bibr5-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1002\/art.10368"},{"key":"bibr6-0192623319878398","unstructured":"Occupational Safety and Health Administration. Workers\u2019 Exposure to Respirable Crystalline Silica: Final Rule Overview. Occupational Safety and Health Administration. 2016. https:\/\/www.osha.gov\/Publications\/OSHA3683.pdf. Accessed June 25, 2019."},{"key":"bibr7-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60235-9"},{"key":"bibr8-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-1014OC"},{"key":"bibr9-0192623319878398","first-page":"1","author":"Kawasaki H","year":"2019","journal-title":"Inhal Toxicol"},{"key":"bibr10-0192623319878398","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2015.1066905"},{"key":"bibr11-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1080\/08958370490270936"},{"key":"bibr12-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125481"},{"key":"bibr13-0192623319878398","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306069346"},{"key":"bibr14-0192623319878398","doi-asserted-by":"crossref","unstructured":"Hill AB. The environment and disease: association or causation? Proc R Soc Med. 1965;58:295\u2013300. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14283879. 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NZB\/NZW mice as a model of systemic lupus erythematosus. JAMA. 1966;195(4):285\u2013289. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4159181. 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