{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:01:32Z","timestamp":1777914092883,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"PolyPid Ltd."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n                    Surgical site infections (SSIs) are a common surgical-related complication. To avoid these complications, a new biodegradable polymer\u2013lipid encapsulation matrix that provides controlled release of doxycycline (doxycycline\/polymer-lipid encapsulation matrix [D-PLEX]) has been developed. The aim of this comprehensive study was to evaluate the potential safety of D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    in abdominal surgical site. D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    was administered into incisions of abdominal surgical site in Yucatan miniature swine, which were followed for up to 6 months and compared to sham-control swine. The D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    mass did not migrate from the incisional site, and there was no evidence for systemic toxicity or other safety concerns. Surgical incision sites, including the peritoneal surface, were fully healed at 6 months in all animals. Most of the D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    mass was absorbed during the first 3 months, and by 6 months, D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    was fully absorbed. Toxicokinetic evaluation revealed that doxycycline concentrations were evident at 30 minutes and persisted to 8 days (71 mg\/kg) or at least 15 days (284 mg\/kg) and were no longer present in plasma by day 29. This study supports the safety of D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    and its favorable degradability profile. A clinical study is being performed to assess the safety and the efficacy of D-PLEX\n                    <jats:sub>100<\/jats:sub>\n                    to prevent human abdominal SSIs.\n                  <\/jats:p>","DOI":"10.1177\/0192623320928902","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T09:44:51Z","timestamp":1591868691000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["D-PLEX\n                    <sub>100<\/sub>\n                    in an Abdominal Surgery Incision Model in Miniature Swine: Safety Study"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-8385","authenticated-orcid":false,"given":"Yuval","family":"Ramot","sequence":"first","affiliation":[{"name":"Hadassah Medical Center, Hebrew University of Jerusalem, the Faculty of Medicine, Jerusalem, 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