{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:01:30Z","timestamp":1777914090915,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>The National Toxicology Program (NTP) has recently introduced the practice of examining longitudinal histological sections of the female rodent uterus to improve the identification of non-neoplastic lesions, preneoplastic lesions, and uterine tumors. This practice has created a need for reference material that includes normal histology, spontaneous lesions, and inducible lesions in longitudinal as well as transverse sections of the body of the uterus, uterine horns, cervix and vagina. Using 3 archived NTP reproductive and developmental toxicity studies, the authors reviewed longitudinal and transverse sections of uteri from female Hsd:Sprague Dawley SD\u00ae (Hsd:SD) rats for cystic endometrial hyperplasia (CEH). The purposes of this review were to (1) evaluate if existing criteria for CEH in transverse uterine sections could be applied to longitudinal sections to develop diagnostic features of CEH in longitudinal uterine sections of rat uterus and (2) create an atlas of the normal estrous cycle phases in longitudinal sections of young and mature adult Hsd:SD rat uteri. The information provided in this original article should help facilitate the examination of longitudinal sections of the uterus in future commercial and governmental rodent studies.<\/jats:p>","DOI":"10.1177\/0192623320931768","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T03:32:31Z","timestamp":1592278351000},"page":"616-632","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats"],"prefix":"10.1177","volume":"48","author":[{"given":"Kristen R.","family":"Hobbie","sequence":"first","affiliation":[{"name":"Integrated Laboratory Systems, Inc, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-2985","authenticated-orcid":false,"given":"Darlene","family":"Dixon","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"bibr1-0192623320931768","doi-asserted-by":"publisher","DOI":"10.1177\/0192623316672074"},{"key":"bibr2-0192623320931768","volume-title":"NTP Technical Report on the Toxicology Studies of Tetrabromobisphenol A (CAS NO. 79-94-7) in F344\/NTac Rats and B6C3F1\/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl: WI(Han)] Rats and B6C3F1\/N Mice (Gavage Studies)","author":"National Toxicology Program"},{"key":"bibr3-0192623320931768","unstructured":"Elmore SA. Longitudinal residual evaluations for identifying uterine proliferative lesions. National Institute of Environmental Health Sciences NTP Technical Reports Peer Review Meeting. National Toxicology Program website; 2014. Accessed 30 June 2019. https:\/\/ntp.niehs.nih.gov\/ntp\/about_ntp\/trpanel\/2014\/may\/presentations\/03uteruspathelmore_508.pdf"},{"key":"bibr4-0192623320931768","unstructured":"National Toxicology Program. Historical Controls. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC. National Toxicology Program website. Saunders Elsevier; 2012:101\u2013121. Accessed July 25, 2019. https:\/\/ntp.niehs.nih.gov\/results\/dbsearch\/historical\/index.html"},{"key":"bibr5-0192623320931768","unstructured":"National Toxicology Program. Specifications for the conduct of studies to evaluate the toxic and carcinogenic potential of chemical, biological and physical agents in laboratory animals for the national toxicology program (NTP), January 2011. National Toxicology Program website. Accessed June 30, 2019. https:\/\/ntp.niehs.nih.gov\/ntp\/test_info\/finalntp_toxcarspecsjan2011.pdf."},{"key":"bibr6-0192623320931768","doi-asserted-by":"publisher","DOI":"10.1078\/0940-2993-00311"},{"key":"bibr7-0192623320931768","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391448-4.00027-7"},{"key":"bibr8-0192623320931768","first-page":"409","volume-title":"Pathology of the Mouse: Reference and Atlas","author":"Davis BJ","year":"1999","edition":"1"},{"key":"bibr9-0192623320931768","doi-asserted-by":"publisher","DOI":"10.1293\/tox.27.1S"},{"key":"bibr10-0192623320931768","unstructured":"Willson G, Cimon KY. Uterus\u2014uterus, endometrium\u2014hyperplastic, cystic. In: Cesta MF, Herbert RA, Brix A, Malarkey DE, Sills RC, eds. National Toxicology Program Nonneoplastic Lesion Atlas. National Toxicology Program website; 2015. Accessed June, 30 2019. https:\/\/ntp.niehs.nih.gov\/nnl\/female_reproductive\/uterus\/enhypc\/index.htm."},{"key":"bibr11-0192623320931768","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308315665"},{"key":"bibr12-0192623320931768","unstructured":"Willson G, Cimon KY. Female reproductive system\u2014uterus. In: Cesta MF, Herbert RA, Brix A, Malarkey DE, Sills RC, eds. The National Toxicology Program Nonneoplastic Lesion Atlas. National Toxicology Program website; 2015. Accessed June 30, 2019. https:\/\/ntp.niehs.nih.gov\/nnl\/female_reproductive\/uterus\/authors\/uterus_authors_and_reviewers.htm."},{"key":"bibr13-0192623320931768","first-page":"443","volume-title":"Pathology of the Fischer Rat","author":"Leininger JR","year":"1990"},{"key":"bibr14-0192623320931768","unstructured":"National Toxicology Program. Specifications for the conduct of studies to evaluate the reproductive and developmental toxicity of chemical, biological and physical agents in laboratory animals for the National Toxicology Program (NTP), May 2011. National Toxicology Program Website. 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