{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:01:34Z","timestamp":1777914094472,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>\n                    Glutathione S-transferase placental form-positive (GST-P\n                    <jats:sup>+<\/jats:sup>\n                    ) foci are markers of preneoplastic lesions in rat hepatocarcinogenesis. Our previous studies using reporter gene transgenic rats showed that furan, a hepatocarcinogen in rodents, rapidly induces the formation of GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci after short exposure without reporter gene mutation. We hypothesized that GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci induced by furan may have biological characteristics different from those induced by diethylnitrosamine (DEN), a genotoxic hepatocarcinogen. Accordingly, we compared the cell kinetics of GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci after cessation of DEN treatment and performed comprehensive gene expression in DEN- or furan-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci. The number and area of DEN-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci were increased after cessation of treatment, whereas furan decreased these parameters. Size distribution analysis showed that large furan-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci disappeared after cessation of treatment. Hierarchical cluster analysis showed that all samples from GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci induced by furan were separated from those induced by DEN. SOX9 expression was upregulated in furan-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci and was detected by immunohistochemistry in large furan-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci. Our results indicated that large furan-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci were quite different from DEN-induced GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci at the molecular and cellular levels. And one of the properties of disappearing large GST-P\n                    <jats:sup>+<\/jats:sup>\n                    foci were characterized by inclusion of hepatocytes expressing SOX9.\n                  <\/jats:p>","DOI":"10.1177\/0192623320948782","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T12:11:50Z","timestamp":1598271110000},"page":"756-765","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Furan Induced Characteristic Glutathione\n                    <i>S<\/i>\n                    -Transferase Placental Form-Positive Foci in Terms of Cell Kinetics and Gene Expression"],"prefix":"10.1177","volume":"48","author":[{"given":"Shinji","family":"Takasu","sequence":"first","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Kijima","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae","family":"Nakane","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan"},{"name":"Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-8759","authenticated-orcid":false,"given":"Takashi","family":"Umemura","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, Kanagawa, Japan"},{"name":"Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"bibr1-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01343.x"},{"key":"bibr2-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1177\/019262338501300402"},{"key":"bibr3-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3331"},{"key":"bibr4-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs294"},{"key":"bibr5-0192623320948782","unstructured":"National Toxicology Program. Toxicology and carcinogenesis studies of furan (CAS No. 110-00-9) in F344\/N rats and B6C3Fl mice (gavage studies). NTP Technical Report No. 402. 1993."},{"key":"bibr6-0192623320948782","unstructured":"National Toxicology Program. NTP toxicology and carcinogenesis studies of methyleugenol (CAS NO. 93-15-2) in F344\/N rats and B6C3F1 mice (gavage studies). NTP Technical Report No. 491. 2000."},{"key":"bibr7-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308315671"},{"key":"bibr8-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.09.088"},{"key":"bibr9-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20061"},{"key":"bibr10-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0865-8"},{"key":"bibr11-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.07.003"},{"key":"bibr12-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-009-0461-8"},{"key":"bibr13-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01705.x"},{"issue":"7","key":"bibr14-0192623320948782","first-page":"1","volume":"8","author":"Salmonella mutagenicity tests: II","year":"1986","journal-title":"Environ Mutagen"},{"key":"bibr15-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1021\/tx000065f"},{"key":"bibr16-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.08.014"},{"key":"bibr17-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.051"},{"key":"bibr18-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940070110"},{"key":"bibr19-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.3.545"},{"key":"bibr20-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-004-0265-0"},{"key":"bibr21-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.08.014"},{"key":"bibr22-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh030"},{"key":"bibr23-0192623320948782","doi-asserted-by":"publisher","DOI":"10.3109\/08830189509056711"},{"key":"bibr24-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.03.013"},{"key":"bibr25-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.07.010"},{"key":"bibr26-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1101-4"},{"key":"bibr27-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1038\/ng.722"},{"key":"bibr28-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.026"},{"key":"bibr29-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.01.010"},{"key":"bibr30-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-007-0309-3"},{"key":"bibr31-0192623320948782","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23488"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623320948782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0192623320948782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623320948782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:41:12Z","timestamp":1777653672000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0192623320948782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/0192623320948782"],"URL":"https:\/\/doi.org\/10.1177\/0192623320948782","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}