{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:01:40Z","timestamp":1777914100216,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p>Differentiating test article\u2013related vascular changes from spontaneous findings is important for microscopic interpretation in drug safety evaluation studies intended for regulatory submission. Here, we report background spontaneous hepatic artery degeneration and necrosis in up to 20% of 3- to 9-month-old control male Sprague-Dawley rats in 23 individual safety studies. The vascular degeneration occurred in one cross section of a medium-sized hepatic artery near the hilus and ranged from acute intramural hemorrhage and fibrinoid necrosis to chronic fibrosis of the vascular wall with perivascular edema, hemorrhage, and inflammatory cell infiltrates. The cause was uncertain. Many microscopic features were consistent with systemic necrotizing arteriopathy (SNA) or polyarteritis; however, there was no change in arteries commonly affected in SNA\/polyarteritis (mesenteric, pancreatic, or testicular arteries) and hepatic artery degeneration\/necrosis occurred in younger rats which is unusual for SNA\/polyarteritis. Spontaneous hepatic artery degeneration\/necrosis represents a sporadic background finding that may be confused with a test article\u2019s toxicologic effect.<\/jats:p>","DOI":"10.1177\/0192623320960724","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T09:26:57Z","timestamp":1601026017000},"page":"905-908","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous Necrotizing Hepatic Arteriopathy in Male Sprague-Dawley Rats"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-8678","authenticated-orcid":false,"given":"Tracy","family":"Carlson","sequence":"first","affiliation":[{"name":"Charles River Laboratories Inc, Mattawan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Yee","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"bibr1-0192623320960724","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314524490"},{"key":"bibr2-0192623320960724","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53856-7.00007-5"},{"key":"bibr3-0192623320960724","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314525687"},{"key":"bibr4-0192623320960724","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1201\/b13783","volume-title":"Toxicologic Pathology, Nonclinical Safety Assessment","author":"Sahota PS","year":"2013"},{"key":"bibr5-0192623320960724","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391448-4.00030-7"},{"key":"bibr6-0192623320960724","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.22.105"},{"key":"bibr7-0192623320960724","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00778.x"},{"key":"bibr8-0192623320960724","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-89-21756"},{"key":"bibr9-0192623320960724","unstructured":"Carlson T, Yee L. Spontaneous hepatic artery degeneration\/necrosis in young male Sprague-Dawley rats. Poster presented at: Keeping it Renal. 37th Annual Symposium of the Society of Toxicologic Pathology; June 16-21, 2018; Indianapolis, IN."},{"issue":"6","key":"bibr10-0192623320960724","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1177\/019262339802600616","volume":"26","author":"Short BG","year":"1998","journal-title":"Toxicol Pathol"},{"issue":"2","key":"bibr11-0192623320960724","first-page":"201","volume":"14","author":"Wilens SL","year":"1938","journal-title":"Am J Pathol"},{"issue":"3","key":"bibr12-0192623320960724","first-page":"1S","volume":"29","author":"Berridge BR","year":"2016","journal-title":"Toxicol Pathol"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623320960724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0192623320960724","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0192623320960724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:41:21Z","timestamp":1777653681000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0192623320960724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1177\/0192623320960724"],"URL":"https:\/\/doi.org\/10.1177\/0192623320960724","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}