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Anatomy and physiology are conserved among vertebrate eyes, and studies with common mammalian preclinical species (rodent, dog) can predict human ocular toxicity. However, since the eye is susceptible to toxicities that may not involve a histological correlate, and these species rely heavily on smell and hearing to navigate their world, discovering visual deficits can be challenging with traditional animal models. Alternative models capable of identifying functional impacts on vision and requiring minimal amounts of chemical are valuable assets to toxicology. Human and zebrafish eyes are anatomically and functionally similar, and it has been reported that several common human ocular toxicants cause comparable toxicity in zebrafish. Vision develops rapidly in zebrafish; the tiny larvae rely on visual cues as early as 4 days, and behavioral responses to those cues can be monitored in high-throughput fashion. This article describes the comparative anatomy of the zebrafish eye, the notable differences from the mammalian eye, and presents practical applications of this underutilized model for assessment of ocular toxicity.<\/jats:p>","DOI":"10.1177\/0192623320964748","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T06:02:41Z","timestamp":1602828161000},"page":"438-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Zebrafish as an Animal Model for Ocular Toxicity Testing: A Review of Ocular Anatomy and Functional Assays"],"prefix":"10.1177","volume":"49","author":[{"given":"Steven","family":"Cassar","sequence":"first","affiliation":[{"name":"Preclinical Safety, AbbVie, Inc, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Dunn","sequence":"additional","affiliation":[{"name":"Preclinical Safety, AbbVie, Inc, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-4740","authenticated-orcid":false,"given":"Meg Ferrell","family":"Ramos","sequence":"additional","affiliation":[{"name":"Preclinical Safety, AbbVie, Inc, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"bibr1-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5b00407"},{"issue":"2","key":"bibr2-0192623320964748","first-page":"289","volume":"36","author":"Beilmann M","year":"2019","journal-title":"ALTEX"},{"key":"bibr3-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.12.008"},{"key":"bibr4-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1177\/026119290903700307"},{"issue":"2","key":"bibr5-0192623320964748","first-page":"120","volume":"54","author":"Tannenbaum J","year":"2015","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"bibr6-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2011.06.121"},{"key":"bibr7-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104662"},{"key":"bibr8-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-27378-1_24"},{"key":"bibr9-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00335"},{"key":"bibr10-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2020.105542"},{"key":"bibr11-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2020.05.004"},{"key":"bibr12-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2018.06.005"},{"key":"bibr13-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.09.163"},{"key":"bibr14-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00459"},{"key":"bibr15-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.53.2.126"},{"key":"bibr16-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374814-0.00023-9"},{"key":"bibr17-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.53.2.179"},{"key":"bibr18-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2016.1299"},{"key":"bibr19-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22113"},{"key":"bibr20-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"bibr21-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-019-9_3"},{"key":"bibr22-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa085"},{"key":"bibr23-0192623320964748","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.10.005"},{"key":"bibr24-0192623320964748","first-page":"65","volume-title":"Advances in Genetics. 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