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The Society of Toxicologic Pathology (STP) has produced generic \u201cbest practice\u201d recommendations for nervous system sampling in nonrodents during general toxicity studies ( Toxicol Pathol 41[7]: 1028\u20131048, 2013), but their adaptation to the minipig has not been attempted. Here, we describe 2 trimming schemes suitable for evaluating the unique neuroanatomic features of the minipig brain in nonclinical toxicity studies. The first scheme is intended for general toxicity studies (Tier 1) to screen agents with unknown or no anticipated neurotoxic potential; this approach using 7 coronal hemisections accords with the published STP \u201cbest practice\u201d recommendations. The second trimming scheme for neurotoxicity studies (Tier 2) uses 14 coronal hemisections and 2 full coronal sections to investigate toxicants where the nervous system is a suspected or known target organ. Collection of spinal cord, ganglia (somatic and autonomic), and nerves from minipigs during nonclinical studies should follow published STP \u201cbest practice\u201d recommendations for sampling the central (CNS, Toxicol Pathol 41[7]: 1028\u20131048, 2013) and peripheral (PNS, Toxicol Pathol 46[4]: 372\u2013402, 2018) nervous systems.<\/jats:p>","DOI":"10.1177\/01926233211019941","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T05:21:53Z","timestamp":1629696113000},"page":"1140-1163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the G\u00f6ttingen Minipig"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-3804","authenticated-orcid":false,"given":"Ingrid 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