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The most prominent microscopic finding was focal dilation with disruption of the wall of the ascending aorta with chronic adventitial inflammation or fibroplasia. The pathogenesis of this finding is unknown. There were no associated macroscopic findings, clinical abnormalities, or vascular lesions elsewhere. The results of a search of historical control data from toxicology studies of 1 day to 72 weeks\u2019 duration performed at CRL for aortic findings from 5900 mice and 23,662 rats are also reported. Aortic lesions are uncommon in mice and rats used in nonclinical safety studies, but toxicologic pathologists should be aware that aneurysms of the ascending aorta with fibroplasia and inflammation in the aortic wall and adventitia may occur spontaneously or iatrogenically, as they have the potential to impact interpretation in toxicology studies.<\/jats:p>","DOI":"10.1177\/01926233211056872","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T13:45:23Z","timestamp":1638452723000},"page":"4-12","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat"],"prefix":"10.1177","volume":"50","author":[{"given":"Daniel","family":"Petkov","sequence":"first","affiliation":[{"name":"Charles River Laboratories, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-7904","authenticated-orcid":false,"given":"Daniel J.","family":"Patrick","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Mattawan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petrina","family":"Rogerson","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rehagen","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Mattawan, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayle","family":"Hennig","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Senneville, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-8780","authenticated-orcid":false,"given":"Alys","family":"Bradley","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-2816","authenticated-orcid":false,"given":"Paul","family":"Howroyd","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Edinburgh, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Czajkowski","sequence":"additional","affiliation":[{"name":"Melissa Czajkowski, Charles River Laboratories, \u2018s-Hertogenbosch, the Netherlands. 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