{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:45:14Z","timestamp":1779245114160,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Lipopolysaccharide (LPS) may influence hepatic macrophages and autophagy. We evaluated the potential participation of macrophages and autophagosomes in thioacetamide (TAA)-induced rat liver injury under pretreatment of a low dose LPS (0.1 mg\/kg BW, intraperitoneally; nonhepatotoxic dose). F344 rats were pretreated with LPS (LPS + TAA) or saline (TAA alone) at 24 hours before TAA injection (100 mg\/kg BW, intraperitoneally); rats were examined on Days 0 (controls), 1, 2, and 3 after TAA injection. Data were compared between TAA alone and LPS + TAA rats. LPS pretreatment significantly reduced TAA-induced hepatic lesion (centrilobular necrosis with inflammation) on Days 1 and 2, being reflected by declined hepatic enzyme values and decreased number of apoptotic cells. LC3B-immunoreacting autophagosomes (as cytoplasmic fine granules) were significantly increased on Days 1 and 2 in hepatocytes of LPS + TAA rats. In LPS + TAA rats, hepatic macrophages reacting to CD68, CD163, and MHC class II mainly on Day 2 and mRNA levels of macrophage-related factors (MCP-1, IL-1\u03b2, and IL-4) on Day 1 were significantly decreased. Collectively, the low-dose LPS pretreatment might act as cytoprotection against TAA-induced hepatotoxicity through increased autophagosomes and decreased hepatic macrophages, although the dose\/time-dependent cytoprotection of LPS should be further investigated at molecular levels.<\/jats:p>","DOI":"10.1177\/01926233221076758","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T05:49:05Z","timestamp":1644472145000},"page":"353-365","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-5798","authenticated-orcid":false,"given":"Munmun","family":"Pervin","sequence":"first","affiliation":[{"name":"Osaka Prefecture University, Osaka, Japan"},{"name":"Bangladesh Agricultural University, Mymensingh, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Rabiul","family":"Karim","sequence":"additional","affiliation":[{"name":"Osaka Prefecture University, Osaka, Japan"},{"name":"Bangladesh Agricultural University, Mymensingh, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Kuramochi","sequence":"additional","affiliation":[{"name":"Osaka Prefecture University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Izawa","sequence":"additional","affiliation":[{"name":"Osaka Prefecture University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Kuwamura","sequence":"additional","affiliation":[{"name":"Osaka Prefecture University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[{"name":"Osaka Prefecture University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"bibr1-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215570087"},{"key":"bibr2-01926233221076758","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.688780"},{"key":"bibr3-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00193-1"},{"key":"bibr4-01926233221076758","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40128"},{"issue":"6","key":"bibr5-01926233221076758","first-page":"653","volume":"36","author":"Du H-J","year":"2021","journal-title":"Histol Histopathol"},{"key":"bibr6-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1177\/0192623315621191"},{"key":"bibr7-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318801574"},{"key":"bibr8-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.04.003"},{"key":"bibr9-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-011-0889-9"},{"key":"bibr10-01926233221076758","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.8.10168"},{"key":"bibr11-01926233221076758","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020300"},{"key":"bibr12-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200412022"},{"key":"bibr13-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103966"},{"key":"bibr14-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818754967"},{"key":"bibr15-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1038685"},{"key":"bibr16-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"bibr17-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1038\/35056522"},{"key":"bibr18-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.07.003"},{"key":"bibr19-01926233221076758","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21238998"},{"key":"bibr20-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.185"},{"key":"bibr21-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2005.01.011"},{"key":"bibr22-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26615"},{"key":"bibr23-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2015.11.003"},{"key":"bibr24-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141670"},{"key":"bibr25-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309335634"},{"issue":"4","key":"bibr26-01926233221076758","first-page":"497","volume":"29","author":"Wijesundera KK","year":"2014","journal-title":"Histol Histopathol"},{"key":"bibr27-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6189-2.00090-1"},{"key":"bibr28-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.8.5053"},{"key":"bibr29-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.01049.x"},{"key":"bibr30-01926233221076758","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4680"},{"key":"bibr31-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24690"},{"key":"bibr32-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24459"},{"key":"bibr33-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.041"},{"key":"bibr34-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.07.005"},{"key":"bibr35-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00473-5"},{"key":"bibr36-01926233221076758","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.03.007"},{"key":"bibr37-01926233221076758","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010070"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01926233221076758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/01926233221076758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/01926233221076758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:42:33Z","timestamp":1777653753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/01926233221076758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/01926233221076758"],"URL":"https:\/\/doi.org\/10.1177\/01926233221076758","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]}}}