{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:21:43Z","timestamp":1783383703223,"version":"3.54.6"},"reference-count":65,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K06415"],"award-info":[{"award-number":["20K06415"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Iron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ). Hepatic and systemic iron overload were seen in the 0.8% and 1% Fe groups. Twenty-four hours after administration, hepatocellular necrosis induced by TAA and hepatocellular necrosis, degeneration, and vacuolation induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    , as well as serum transaminase values, were exacerbated in the 0.8% and 1% Fe groups compared to the Cont group. On the other hand, microvesicular vacuolation induced by CCl\n                    <jats:sub>4<\/jats:sub>\n                    was decreased in 0.8% and 1% Fe groups. Hepatocellular DNA damage was increased by iron overload in both models, whereas a synergistic effect of oxidative stress by excess iron and hepatotoxicant was only present in the CCl\n                    <jats:sub>4<\/jats:sub>\n                    model. The data showed that dietary iron overload exacerbates TAA- and CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced acute liver injury with different mechanisms.\n                  <\/jats:p>","DOI":"10.1177\/01926233241235623","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:45:10Z","timestamp":1711417510000},"page":"55-66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Difference in the Mechanism of Iron Overload\u2013Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9111-5791","authenticated-orcid":false,"given":"Yohei","family":"Inai","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-6050","authenticated-orcid":false,"given":"Takeshi","family":"Izawa","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Kamei","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Kuwamura","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"bibr1-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0110-9"},{"key":"bibr2-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318776887"},{"key":"bibr3-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27662"},{"key":"bibr4-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.05.014"},{"key":"bibr5-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.7.1340"},{"key":"bibr6-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00298-4"},{"key":"bibr7-01926233241235623","doi-asserted-by":"publisher","DOI":"10.3390\/nu10020175"},{"key":"bibr8-01926233241235623","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101400"},{"key":"bibr9-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"bibr10-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(00)70026-6"},{"key":"bibr11-01926233241235623","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2001-7-826"},{"key":"bibr12-01926233241235623","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.232124"},{"key":"bibr13-01926233241235623","unstructured":"Chaudhry R, Usama SM, Babiker HM. 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