{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:03:04Z","timestamp":1777914184020,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n A 28-year-old, female Rhesus macaque (\n Macaca mulatta<\/jats:italic>\n ) was lethargic and inappetent despite supportive treatment. Euthanasia was elected. Necropsy revealed numerous nodules in the liver and lung. Microscopically, the liver and lung were multifocally effaced by a poorly demarcated proliferation of neoplastic epithelial cells arranged in irregular and tortuous tubules and nests. Neoplastic cells showed positive immunolabeling for CK7 and negative immunolabeling for Hep-Par1. Findings in the liver and lung were consistent with cholangiocarcinoma, which is a rare neoplasm in non-human primates and has not been previously reported as a spontaneous finding in laboratory-kept Rhesus macaques. Rhesus macaques exhibit increased tumor incidence with age similar to humans, emphasizing the need for a comprehensive understanding of spontaneous neoplasia in this species.\n <\/jats:p>","DOI":"10.1177\/01926233251353515","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T06:18:26Z","timestamp":1753078706000},"page":"623-625","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrahepatic Cholangiocarcinoma With Pulmonary Metastasis in a Rhesus Macaque (\n Macaca mulatta<\/i>\n )"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8362-9451","authenticated-orcid":false,"given":"Andressa Varella","family":"Gonsioroski","sequence":"first","affiliation":[{"name":"Michigan State University, Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Michigan State University, Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith Leigh","family":"Cronin","sequence":"additional","affiliation":[{"name":"Inotiv LLC, Venice, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Vetter","sequence":"additional","affiliation":[{"name":"Inotiv, Inc., Kalamazoo, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.3.B212"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00300-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588001700512"},{"issue":"1","key":"e_1_3_3_5_2","article-title":"Extrahepatic cholangiocarcinoma in an adult black howler monkey (Primates: Atelidae)","volume":"41","author":"de Santi M","year":"2019","unstructured":"de Santi M, Couto CD, Montanhim GL, et al. 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