{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:03:08Z","timestamp":1777914188505,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421307\/2016-1"],"award-info":[{"award-number":["421307\/2016-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    This study compared the susceptibility of female Sprague-Dawley (SD) and Wistar-Hannover (WH) rats to chemically induced renal mesenchymal tumors (RMTs) and mammary tumors (MTs). Twenty-one-day-old female rats of each strain received a single dose of N-methyl-N-nitrosourea (MNU). The appearance of palpable tumors was assessed weekly until the animals reached 250 days of age. The incidence rates for both RMTs and MTs were 40% (WH) and 12% (SD) and 92% (SD) and 16% (WH), respectively. Female SD rats developed a high incidence (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) of MTs positive for estrogen receptor-alpha (ER-\u03b1) and progesterone receptor (PR), showing a short latency, rapid growth, and early euthanasia, resulting in a low number of RMTs. Female WH rats developed a low incidence of MNU-induced MTs associated with a long latency. In contrast, they exhibited a high incidence (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .053, trend) and number of slowly growing RMTs, which showed variable immunopositivity for vimentin and alpha-smooth muscle actin (\u03b1-SMA). The female SD rat strain was more susceptible to developing MTs, whereas the female WH rat strain was more suitable for developing RMTs.\n                  <\/jats:p>","DOI":"10.1177\/01926233251393165","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:34:30Z","timestamp":1772195670000},"page":"187-193","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of Chemically Induced Renal Mesenchymal and Mammary Tumors in Female Sprague-Dawley and Wistar Rats"],"prefix":"10.1177","volume":"54","author":[{"given":"Maria Clara de Oliveira","family":"Duarte","sequence":"first","affiliation":[{"name":"UNESP-S\u00e3o Paulo State University, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-2199","authenticated-orcid":false,"given":"Iago Sabino Queiros de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"UNESP-S\u00e3o Paulo State University, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-8380","authenticated-orcid":false,"given":"Guilherme Ribeiro","family":"Romualdo","sequence":"additional","affiliation":[{"name":"UNESP-S\u00e3o Paulo State University, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Marchesan","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"UNESP-S\u00e3o Paulo State University, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Cristina","family":"da Silva","sequence":"additional","affiliation":[{"name":"USP-University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Cogliati","sequence":"additional","affiliation":[{"name":"USP-University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-1814","authenticated-orcid":false,"given":"Lu\u00eds Fernando","family":"Barbisan","sequence":"additional","affiliation":[{"name":"UNESP-S\u00e3o Paulo State University, Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.02.014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2021.106998"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.9.2023"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9581-3_12"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312438736"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318797071"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623316638960"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/157.1.331"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2014.07.006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-267"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-024-09566-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314532036"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1293\/tox.17.131"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100745"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026495322596"},{"issue":"3","key":"e_1_3_2_17_2","first-page":"229","article-title":"Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl- and N-nitrosomethylurea","volume":"27","author":"Turusov VS","year":"1980","unstructured":"Turusov VS, Alexandrov VA, Timoshenko IV. Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl- and N-nitrosomethylurea. 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