{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:03:13Z","timestamp":1777914193701,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>This short communication describes a spontaneous hemangiosarcoma within the abdomen, which appeared to have originated from the prostate gland area with infiltration, and that metastasized to the lungs in a 46-week-old male Sprague-Dawley rat. At necropsy, a 90 mm \u00d7 60 mm \u00d7 50 mm dark cystic neoplastic mass was present in the abdomen and the lung lobes had multiple dark cystic neoplastic structures. The abdominal mass was necrotic with a few peripheral areas of plump oval cells and frond-like structures lined by spindle-shaped cells. The lung neoplastic cysts were filled with blood and there were foci of plump oval cells within and peripheral to the cysts, as well as multiple small clusters throughout the lung parenchyma. Neoplastic cells of the abdominal mass and lung cysts stained positively for von Willebrand Factor by immunohistochemistry, indicating a vascular endothelial cell origin and consistent with a diagnosis of hemangiosarcoma. The lung hemangiosarcomas were considered metastases from the abdominal hemangiosarcoma based on their similar cellular morphology and multiple foci throughout the lung lobes.<\/jats:p>","DOI":"10.1177\/01926233261419482","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:19:35Z","timestamp":1772011175000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Abdominal Hemangiosarcoma With Metastases to the Lungs in a Control Sprague-Dawley Rat"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8295-0188","authenticated-orcid":false,"given":"Gayle","family":"Hennig","sequence":"first","affiliation":[{"name":"Charles River Laboratories, Senneville, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Guy","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Senneville, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthafar","family":"Al-Haddawi","sequence":"additional","affiliation":[{"name":"BMS, New Brunswick, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"International harmonization of nomenclature and diagnostic criteria (INHAND): nonproliferative and proliferative lesions of the cardiovascular system of the rat and mouse, and nonproliferative and proliferative lesions of the rat and mouse skeletal tissues (bones, joints, and teeth)","volume":"29","author":"Berridge BR","year":"2016","unstructured":"Berridge BR, Mowat V, Nagai H, et al. International harmonization of nomenclature and diagnostic criteria (INHAND): nonproliferative and proliferative lesions of the cardiovascular system of the rat and mouse, and nonproliferative and proliferative lesions of the rat and mouse skeletal tissues (bones, joints, and teeth). Toxicol Pathol. 2016;29(3 suppl):30S.","journal-title":"Toxicol Pathol"},{"key":"e_1_3_3_3_2","first-page":"600","volume-title":"Boorman\u2019s Pathology of the Rat","author":"Bradley AE","unstructured":"Bradley AE, Fant P, Guionaud S, et al. Chapter 30-cardiovascular system. In: Suttie AW, Leininger JR, Bradley AE, eds. Boorman\u2019s Pathology of the Rat. 2nd ed. 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