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Dose-related decreases in survival were evident for the groups instilled with the two highest doses of quartz or quartz and ferric oxide. Instillation of quartz or quartz and ferric oxide induced the greatest pulmonary fibrosis in response to the materials tested. However, the dense fibrous tissue present in the lungs in classical human silicosis and in experimental silicosis of rats was not observed in this study. The results of this study indicate that the Syrian golden hamster is not a suitable species for studying the role of quartz-induced pulmonary fibrosis in pulmonary carcinogenesis.<\/jats:p>","DOI":"10.1177\/019262338501300407","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"306-314","source":"Crossref","is-referenced-by-count":17,"title":["Fibrogenic Potential of Intratracheally Instilled Quartz, Ferric Oxide, Fibrous Glass, and Hydrated Alumina in Hamsters"],"prefix":"10.1177","volume":"13","author":[{"given":"Roger A.","family":"Renne","sequence":"first","affiliation":[{"name":"Biology and Chemistry Department and Energy Systems Department, Battelle Pacific Northwest Laboratories, Richland, WA 99352 and Experimental Toxicology Branch, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Robert A. 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