{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:05:49Z","timestamp":1777914349022,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1986,4,1]],"date-time":"1986-04-01T00:00:00Z","timestamp":512697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1986,4]]},"abstract":"<jats:p>The heterotopically transplanted rat urinary bladder (HTB) was developed in our laboratory as a model to study the role of urine in urinary bladder carcinogenesis. With this model, normal urine was found to enhance urinary bladder carcinogenesis initiated by N-methyl-N-nitrosourea or N-butyl-N-(4-hydroxybutyl)nitrosamine. Two crude urinary components (Fractions I and II) were obtained by gel filtration chromatography; they stimulated ornithine decarboxylase (ODC) in a test bladder carcinoma cell line 804G, and promoted carcinogenesis in the HTB system. Fraction I was found to stimulate growth of 804G cells in vitro. Preliminary data indicate that Fraction I contains at least one, and possibly two heat-stable ODC-inducible and mitogenic components. Further characterization of these components is in progress. The HTB system has been demonstrated to be useful for other investigations; for example, \u03b1-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ODC, when instilled repeatedly to the bladder lumen, inhibited tumorigenesis in HTBs.<\/jats:p>","DOI":"10.1177\/019262338601400307","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"331-334","source":"Crossref","is-referenced-by-count":1,"title":["The Heterotopically Transplanted Rat Urinary Bladder as a Model for Detection of Tumor-Promoting Urinary Growth Factor(s)"],"prefix":"10.1177","volume":"14","author":[{"given":"Ryoichi","family":"Oyasu","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishi","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,4,1]]},"reference":[{"key":"atypb1","first-page":"15","volume":"42","author":"Babaya K","year":"1982","journal-title":"Cancer Res."},{"key":"atypb2","first-page":"1774","volume":"43","author":"Babaya K","year":"1983","journal-title":"Cancer Res."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/6.1.159"},{"key":"atypb4","first-page":"648","volume":"45","author":"Homma Y","year":"1985","journal-title":"Cancer Res."},{"key":"atypb5","first-page":"405","volume":"41","author":"Izumi K","year":"1981","journal-title":"Cancer Res."},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)67826-1"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/2.6.495"},{"key":"atypb8","first-page":"2426","volume":"35","author":"O'Brien TG","year":"1975","journal-title":"Cancer Res."},{"key":"atypb9","first-page":"161","volume":"17","author":"Okada M","year":"1975","journal-title":"Gann Monogr. on Cancer Res."},{"key":"atypb10","first-page":"2261","volume":"36","author":"Oyasu R","year":"1976","journal-title":"Cancer Res."},{"key":"atypb11","first-page":"3019","volume":"38","author":"Oyasu R","year":"1978","journal-title":"Cancer Res."},{"key":"atypb12","first-page":"478","volume":"41","author":"Oyasu R","year":"1981","journal-title":"Cancer Res."},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/4.5.547"},{"key":"atypb14","first-page":"4524","volume":"40","author":"Rowland RG","year":"1980","journal-title":"Cancer Res."},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.1980.45.s7.1856"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262338601400307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/019262338601400307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:48:57Z","timestamp":1777654137000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/019262338601400307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,4]]}},"alternative-id":["10.1177\/019262338601400307"],"URL":"https:\/\/doi.org\/10.1177\/019262338601400307","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,4]]}}}