{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:06:24Z","timestamp":1777914384084,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:p>\n                    Hormonal status was evaluated in TCDD-treated rats and in pair-fed and ad libitum- fed controls in order to separate hormonal changes resulting from the toxic insult of TCDD from those arising from progressive feed deprivation as it occurs in pair-fed controls. TCDD-treated rats received either a usually non-lethal (25 \u03bcg\/kg) or a usually lethal (125 \u03bcg\/kg) dose of TCDD whereas pair-fed and ad libitum- fed controls were given vehicle alone. Animals were terminated at predetermined time intervals and several hormones measured in serum or plasma. In addition, the morphology of the thyroid, pancreas, and pituitary was also examined. In both dosage groups, TCDD-treatment had the following effects: decreased TT\n                    <jats:sub>4<\/jats:sub>\n                    , FT\n                    <jats:sub>4<\/jats:sub>\n                    , insulin, and glucagon; mixed effects upon TT\n                    <jats:sub>3<\/jats:sub>\n                    , FT\n                    <jats:sub>3<\/jats:sub>\n                    , TSH, and GH. Pair-feeding to the non-lethal dose of TCDD had no effect on any of the hormones measured. Pair-feeding to the lethal dose of TCDD had the following effects: slightly decreased TT\n                    <jats:sub>4<\/jats:sub>\n                    , FT\n                    <jats:sub>4<\/jats:sub>\n                    , TT\n                    <jats:sub>3<\/jats:sub>\n                    , TSH, and insulin; no effect on FT\n                    <jats:sub>3<\/jats:sub>\n                    and glucagon. It is concluded that the endocrine status of TCDD-treated rats was different from that of pair-fed rats suggesting that some hormonal changes represent responses to an insult other than that due to starvation stress alone. A differential response between TCDD-treated and pair-fed rats was also observable morphologically in the corresponding endocrine glands indicating the importance of this additional control for morphologic observations in instances when reduced-feed intake and body weight loss are prominent features of toxicity.\n                  <\/jats:p>","DOI":"10.1177\/019262338801600301","type":"journal-article","created":{"date-parts":[[2009,9,14]],"date-time":"2009-09-14T21:30:11Z","timestamp":1252963811000},"page":"313-320","source":"Crossref","is-referenced-by-count":48,"title":["Some Endocrine and Morphological Aspects of the Acute Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)"],"prefix":"10.1177","volume":"16","author":[{"given":"Joel R.","family":"Gorski","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Muzi","sequence":"additional","affiliation":[{"name":"Istituto di Medicina del Lavoro, Universita di Perugia, Via E. dal Pozzo, 06100 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz W. D.","family":"Weber","sequence":"additional","affiliation":[{"name":"Gesellschaft f\u00fcr Strahlen- und Umweltforschung mbH M\u00fcnchen, 8042 Neuherberg, Federal Republic of Germany, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Wilbur G. Malcolm Toxicology Laboratories, Medical Research Division, American Cyanamid Company, Pearl River, New York 10965, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray J.","family":"Arceo","sequence":"additional","affiliation":[{"name":"Wilbur G. Malcolm Toxicology Laboratories, Medical Research Division, American Cyanamid Company, Pearl River, New York 10965, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Iatropoulos","sequence":"additional","affiliation":[{"name":"Wilbur G. Malcolm Toxicology Laboratories, Medical Research Division, American Cyanamid Company, Pearl River, New York 10965, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Rozman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107443"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90732-9"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1080\/15287398109530097"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1210\/endo-101-1-292"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90313-3"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(80)90174-X"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(87)90031-X"},{"key":"atypb8","doi-asserted-by":"crossref","unstructured":"8. Gorski JR, Lebofsky M, and Rozman K (1988). Corticosterone decreases toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in hypophysectomized rats. J. Toxicol. Environ. Health (in press).","DOI":"10.1080\/15287398809531214"},{"key":"atypb9","doi-asserted-by":"crossref","unstructured":"9. Gorski JR, Muzi G, Weber LWD, Pereira DW, Iatropoulos M, and Rozman K (1988). Elevated plasma corticosterone levels and histopathology of the adrenals and thymuses in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Toxicology (submitted).","DOI":"10.1016\/0300-483X(88)90233-8"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7305125"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(78)90153-1"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198528030-00017"},{"key":"atypb13","first-page":"682","volume-title":"Williams Textbook of Endocrinology","author":"Ingbar SH","year":"1985","edition":"7"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0560263"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108957"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107000"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-527560-6.50018-4"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1979.tb56602.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-48-5-854"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90415-1"},{"key":"atypb21","first-page":"73","volume-title":"Williams Textbook of Endocrinology","author":"Roth J","year":"1985","edition":"7"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(86)90181-5"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90290-5"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1080\/15287398509530757"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90337-5"},{"key":"atypb26","unstructured":"26. Snedecor G and Cochran N (1980). Statistical Methods, 7th ed. 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